Posttranscriptional regulation gene expression

Identifying the genomic sites that are responsible for gene expression, splicing, posttranscriptional, and other forms of regulation, in cis (i.e., proximal) and in trans (distant), is a critical challenge that deep sequencing is well... 

Polyadenylation is a critical posttranscriptional processing step in the maturation of eukaryotic mRNA [1], The location where the pre-mRNA is cleaved (also known as the poly(A) site) marks the end of a mRNA transcript. Many eukaryotic genes possess two or more poly(A) sites [2-4], and thus are involved in alternative polyadenylation (APA). APA is a powerful pathway that entails the selection of alternate poly(A) sites in a pre-mRNA and leads to the production of multiple mature mRNA isoforms from the same gene, resulting in potential gene expression regulation [1]. 

Alternative Modes of mRNA Splicing Present a Potent Mechanism for Posttranscriptional Regulation Gene Expression Is Also Regulated at the Levels of Translation and Polypeptide Processing Patterns of Regulation Associated with Developmental Processes... 

NOS gene expression can also be regulated at the posttranscriptional level, possibly by altering the stability of the newly transcribed mRNA. In... 

MicroRNAs are small noncoding RNAs 22-25 nucleotides in length, which predominantly serve to negatively regulate posttranscriptional gene expression. Circulating microRNAs... 

The two genes appear to be, at least in a temporal sense, coordinately activated. Because of the simultaneous appearance at G,(3) of both repressor and inducibility, it seems likely that the inducer acts at least indirectly to antagonize the posttranscriptional repressor. Furthermore, the transcriptional control of the S (and R) gene, which does exist, is not steroid-sensitive. Regulation of TAT gene expression clearly occurs at the posttranscriptional level, and the circumstantial evidence suggests that the steroid inducer acts upon the same posttranscriptional function. 

Anderson CJ, Hoare SF, Ashcroft M, Bilsland AE, Keith WN (2006) Hypoxic regulation of telomerase gene expression by transcriptional and posttranscriptional mechanisms. 

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