Polypeptide processing

Posttranslational modifications include many covalent alterations Polypeptide processing, attachment of carbohydrate or lipid groups to specific side chains, and addition of many other low-molecular-weight ligands to side chains. 

Alternative Modes of mRNA Splicing Present a Potent Mechanism for Posttranscriptional Regulation Gene Expression Is Also Regulated at the Levels of Translation and Polypeptide Processing Patterns of Regulation Associated with Developmental Processes... 

Gene Expression Is Also Regulated at the Levels of Translation and Polypeptide Processing... 

Meng F. Abedini A, Song B, Raleigh DP. Amyloid formation by pro-islet amyloid polypeptide processing intermediates examination of the role of protein heparan sulfate interactions and impUcations for islet amyloid formation in type 2 diabetes. Biochemistry 2007 46 12091-12099. 

Indinavir is selectively toxic by potently inhibiting the HIV-encoded protease but not host-encoded aspartyl proteases. Indinavir reversibly binds to the active site of HIV protease, preventing polypeptide processing and subsequent virus maturation. Virus particles are produced in the presence of indinavir but are noninfectious. 

Nelfinavir reversibly binds to the active site of the HIV protease, preventing polypeptide processing and subsequent virus maturation. 

How do the recombinant expression system and the host affect the mature protein stmcture and function Do posttranslational modifications (e.g., glyco-sylation, pre- and pro-polypeptide processing) need to be addressed ... 

Photographic material containing gelatin can be hardened during manufacture the process involves cross-linking between the gelatine polypeptide chains induced by hardener. 

Studies of electrical interactions in proteins, polypeptides, and amino acids started over 60 years ago [1]. To a large extent, electrostatic properties of proteins are determined by the ability of certain amino acids to exchange protons with their environment and the dependence of these processes on pH. The proton occupies a special position as a promoter and iiuxliator in... 

Polyethylene (Section 6 21) A polymer of ethylene Polymer (Section 6 21) Large molecule formed by the repeti tive combination of many smaller molecules (monomers) Polymerase chain reaction (Section 28 16) A laboratory method for making multiple copies of DNA Polymerization (Section 6 21) Process by which a polymer is prepared The principal processes include free radical cationic coordination and condensation polymerization Polypeptide (Section 27 1) A polymer made up of many (more than eight to ten) amino acid residues Polypropylene (Section 6 21) A polymer of propene Polysaccharide (Sections 25 1 and 25 15) A carbohydrate that yields many monosacchande units on hydrolysis Potential energy (Section 2 18) The energy a system has ex elusive of Its kinetic energy... 

Polymer—polymer iacompatibiHty encapsulation processes can be carried out ia aqueous or nonaqueous media, but thus far have primarily been carried out ia organic media. Core materials encapsulated tend to be polar soHds with a finite degree of water solubiHty. EthylceUulose historically has been the sheU material used. Biodegradable sheU materials such as poly(D,L-lactide) and lactide—glycoHde copolymers have received much attention. In these latter cases, the object has been to produce biodegradable capsules that carry proteias or polypeptides. Such capsules tend to be below 100 p.m ia diameter and are for oral or parenteral administration (9). 

Several parenteral microencapsulated products have been commercialized the cote materials ate polypeptides with hormonal activity. Poly(lactide— glycohde) copolymers ate the sheU materials used. The capsules ate produced by solvent evaporation, polymer-polymer phase separation, or spray-dry encapsulation processes. They release their cote material over a 30 day period in vivo, although not at a constant rate. 

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