Posttranscriptional Regulation mRNA Stability

is a Medical Research Council of Canada Scholar. The preparation for this chapter was supported by a grant from the Medical Research Council of Canada and by the Heart and Stroke Foundation. 

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Figure 8-2 Posttranscriptional regulation by IRE/IRP interactions. In iron-replete cells, IRPs do not bind to IREs. Iron starvation induces IRPs to bind to their ligands, resulting in stabilization of transferrin receptor mRNA and translational inhibition of the mRNAs encoding ferritin H- and L-chain), eALAS and mitochondrial aconitase.

NOS gene expression can also be regulated at the posttranscriptional level, possibly by altering the stability of the newly transcribed mRNA. In... 

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