Sterol regulatory element binding proteins

Also, phosphorylation of Akt results in activation of sterol regulatory-element binding protein 1 (SREBP1), a key transcription factor involved in regulation of lipogenic enzymes. In addition, some of the effects of insulin on cell proliferation and survival may be explained by an Akt-dependent inhibition of apoptosis through phosphorylation and inactivation of proa-poptotic proteins (e.g., BAD, Caspase 9). 

Osborne TF. Sterol regulatory element binding protein (SREBPs) Key regulators of nutritional homeostasis and insulin action. J Biol Chem 2000 275 32379-32382. 

Muller PJ, Miserez AR. Mutations in the gene encoding sterol-regulatory element-binding protein-2 in hypercholes-terolaemic subjects. Atherosclerosis Supplements 2001 2 69. 

SREBP sterol regulatory element binding protein... 

FIGURE 21-43 SREBP activation. Sterol regulatory element-binding proteins (SREBPs, shown in green) are embedded in the ER when first synthesized, in a complex with the protein SREBP cleavage-activating protein (SCAP, red). (N and C represent the amino and carboxyl termini of the proteins.) When bound to SCAP, SREBPs are inactive. When... 

Includes a timely new discussion on the regulation of cholesterol metabolism at the genetic level, with consideration of sterol regulatory element-binding proteins (SREBPs). 

Miserez AR, Muller PY, Barella L, Schwietert M, Erb P, Vemazza PL, Battegay M Swiss HIV Cohort Study. A single-nucleotide polymorphism in the sterol-regulatory element-binding protein lc gene is predictive of HTV-related hyperlipoproteinaemia. AIDS 2001 15 2045-9. 

Diomede L, Albani D, Bianchi M, Salmona M. Endotoxin regulates the maturation of sterol regulatory element binding protein-1 through the induction of cytokines. Eur Cytokine Netw 2001 12 625-630. 

Moon, Y. A., Shah, N. A., Mohapatra, S., Warrington, J. A. and Horton, J.D. (2001). Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J. Biol. Chem., 276,45358—45366. 

Shimano, H. 2001. Sterol regulatory element-binding proteins (SREBPs) transcriptional regulators of lipid synthetic genes. Prog. Lipid Res. 40, 439-452. 

Members of a family of nuclear transcription factors called sterol regulatory element-binding proteins (SREBP) are responsible for the regulation of these cholesterol feedback mechanisms. SREBP are able to activate a number of genes encoding for proteins involved in the homeostasis of cholesterol and other lipids, including the LDL receptor gene itself. 

Horton, J. D., Shimomural I., Ikemoto, S., Bashmakov, Y., and Hammer, R. E. 2003. Overexpression of sterol regulatory element-binding protein-la in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver. J. Biol. Chem., 278, 36652-36660. 

Kim, H. J.,Takahashi, M., and Ezaki, 0.1999. Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-lc mRNA in mouse liver a possible mechanism for down-regulation of lipogenic enzyme mRNAs. J. Biol. Chem.,274, 25892-25898. 

Fatty acid synthase is transcriptionally regulated by upstream stimulatory factor and sterol regulatory element binding protein Ic (SREBP-lc), in response to feeding/insulin. 

The sterol regulatory-element-binding proteins (SREBPs)... 

E. A. Duncan, U. P. Dav, J. Sakai, J. L. Goldstein, and M. S. Brown. Second-site cleavage in sterol regulatory element binding protein occurs at transmembrane junenon as determined by cysteine panning. J Biol Chem, 273, 17801-17809, 1998. 

Kuhn, D. J., Bums, A. C., Kazi, A., Dou, Q. P. (2004). Direct inhibition of the ubiquitin-proteasome pathway by ester bond-containing green tea polyphenols is associated with increased expression of sterol regulatory element-binding protein 2 and LDL receptor. Biochim. Biophis. Acta, 1682, 1-10. 

Mullen, E., Brown, R. M., Osborne, T. R, Shay, N. F. (2004). Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells. J. Nutr., 134, 2942-2947. 

Sheng, Z., Otani, H., Brown, M.S., and Goldstein, J.L. (1995). Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc Natl Acad Sci USA 92 935-938. 

Mascaro, C., Ortiz, J.A., Ramos, M.M., Haro, D., and Hegardt, F.G. (2000). Sterol regulatory element binding protein-mediated effect of fluvastatin on cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase transcription. Arch Biochem Biophys 374 286-292. 

Xu, L., and Simoni, R.D. (2003). The inhibition of degradation of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane domain. Arch Biochem Biophys 414 232-243. 

---