Polylactides

Ray et al. [268] also found that the biodegradability of polylactides in bionanocomposites depends completely on both the nature of pristine layered sihcates and surfactants used for the modification of layered silicate. Based on this behavior, they reported that composite biodegradabihty can be controlled by a judicious choice of the organically modified layered silicate (OMLS). 

MMT modified with functionalized ammonium salts [270-277] and layered ti-tanate modified with N-(cocoaLkyl)-N,N-[bis(2-hydroxyethyl)]-N-methylammonium cation [278] were added to PLA in order to produce bionanocomposites with improved mechanical and thermal properties, reduced oxygen permeability, and good biodegradabiUty. Addition of nanoclays was also found to reduce the flammability of the PIA-based bionanocomposites [279]. 

Gorrasi et al. [280] improved water vapor barrier properties by creating bio-nanocomposites of PLA and MMT modified with a functionalized ammonium. 

Both intercalated and ejcfoliated composites were obtained. They concluded that nanocomposite formation yielded better barrier properties specifically when exfo-Hated morphology was obtained. 

Compatibilizers to increase dispersion of nanoclays have also been used in PLA, with a noticeably enhanced degree of exfoliation of the organoclay [285]. Addition of PCL, as a compatibilizer to PLA was also found to improve processabihty and mechanical properties of the bionanocomposites [286]. 

Biodegradable plastics based on lactic acid have been available on a small scale for many years. They have been used In applications such as medical implants, but their high price was a deterrent to widespread use in lower value applications such as packaging. However, new technologies for production of lactide monomers greatly lowered costs, making the polymers much more competitive. Generally, the lactic acid is obtained from corn or other biobased materials by a fermentation process, and then chemical synthesis is used to produce the polymer from the lactic acid or lactide monomers. 

Other producers of PLA resins and related copolymers have included Mitsui Toatsu, Shimatsu, CornCard International, Chronopol, Dainippon, and Neste Oy, but Cargill is by far the largest producer. 

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Poly(ethylene terephthalate), the predominant commercial polyester, has been sold under trademark names including Dacron (Du Pont), Terylene (ICI), Eortrel (Wellman), Trevira (Hoechst-Celanese), and others (17). Other commercially produced homopolyester textile fiber compositions iaclude p oly (1,4-cyc1 oh exa n e- dim ethyl en e terephthalate) [24936-69-4] (Kodel II, Eastman), poly(butylene terephthalate) [26062-94-2] (PBT) (Trevira, Hoechst-Celanese), and poly(ethylene 4-oxyben2oate) [25248-22-0] (A-Tell, Unitika). Other polyester homopolymer fibers available for specialty uses iaclude polyglycoHde [26124-68-5] polypivalolactone [24937-51-7] and polylactide [26100-51-6],... 

Health Safety. PET fibers pose no health risk to humans or animals. Eibers have been used extensively iu textiles with no adverse physiological effects from prolonged skin contact. PET has been approved by the U.S. Eood and Dmg Administration for food packagiug and botties. PET is considered biologically iuert and has been widely used iu medical iaserts such as vascular implants and artificial blood vessels, artificial bone, and eye sutures (19). Other polyester homopolymers including polylactide and polyglycoHde are used iu resorbable sutures (19,47). 

Polylactide is the generaUy accepted term for highly polymeric poly(lactic acid)s. Such polymers are usuaUy produced by polymerization of dilactide the polymerization of lactic acid as such does not produce high molecular weight polymers. The polymers produced from the enantiomeric lactides are highly crystalline, whereas those from the meso lactide are generaUy amorphous. UsuaUy dilactide from L-lactic acid is preferred as a polymerization feedstock because of the avaUabUity of L-lactic acid by fermentation and for the desirable properties of the polymers for various appUcations (1,25). 

Polylactic acid, also known as polylactide, is prepared from the cycHc diester of lactic acid (lactide) by ring-opening addition polymerization, as shown below ... 

PolyglycoHc Acid. PolyglycoHc acid (PGA), also known as polyglycoHde, was first reported in 1893, but it wasn t until 1967 that the first commercially successful patent was granted for sutures (27). Like polylactide, polyglycoHde is synthesized from the cycHc diester as shown below ... 

Polycaprolactones (see also Section 25.11), although available since 1969, have only recently been marketed for biodegradable purposes. Applications include degradable film, tree planting containers and slow-release matrices for pharmaceuticals, pesticides, herbieides and fertilisers. Its rate of biodegradability is said to be less than that of the polylactides. 

Polylactides, 18 Poly lactones, 18, 43 Poly(L-lactic acid) (PLLA), 22, 41, 42 preparation of, 99-100 Polymer age, 1 Polymer architecture, 6-9 Polymer chains, nonmesogenic units in, 52 Polymer Chemistry (Stevens), 5 Polymeric chiral catalysts, 473-474 Polymeric materials, history of, 1-2 Polymeric MDI (PMDI), 201, 210, 238 Polymerizations. See also Copolymerization Depolymerization Polyesterification Polymers Prepolymerization Repolymerization Ring-opening polymerization Solid-state polymerization Solution polymerization Solvent-free polymerization Step-grown polymerization processes Vapor-phase deposition polymerization acid chloride, 155-157 ADMET, 4, 10, 431-461 anionic, 149, 174, 177-178 batch, 167 bulk, 166, 331 chain-growth, 4 continuous, 167, 548 coupling, 467 Friedel-Crafts, 332-334 Hoechst, 548 hydrolytic, 150-153 influence of water content on, 151-152, 154... 

Polymerization of D,L-lactide to polylactide was also achieved using monomeric tin(ll) amidinates (cf. Schemes 48 and and the mono... 

Jacobsen, S. and Fritz, H.G. 1999. Plasticizing polylactide, the effect of different plasticizers on the mechanical properties. Polymer Engineering and Science 39 1303-1310. 

Polylactide (PLA)-CaS04 composites toughened with low molecular weight and polymeric ester-like plasticizers and related performances. European Polymer Journal 44 3842-3852. 

Sinha, R.S., Yamada, K., Okamoto, M. and Ueda, K. 2002. New polylactide/layered silicate nanocomposite A novel biodegradable material. Nano Betters 2 1093-1096. 

Takagi, Y., Yasuda, R., Yamaoka, M. and Yamane, T. 2004. Morphologies and mechanical properties of polylactide blends with medium chain length poly(3-hydroxyalkanoate) and chemically modified poly(3-hydroxyalkanoate). Journal of Applied Polymer Science 93 2363-2369. 

The use of polylactides for delivery of insect hormone analogs and other veterinary compounds (115,116) has been studied. Microspheres, pellets, and reservoir devices based on polyglycolide, poly-(DL-Iactide), poly(L-lactide), and various copolymers have been used to deliver methoprene and a number of juvenile hormone analogs. ... 

Other interesting polyesters of practical relevance are polylactides that are considered to be biologically degradable. Polylactides are prepared by a ring opening... 

Bielaet al. (2002,2003) prepared and analyzed linear and star-shaped polylactides. Using LCCC, star-shaped samples were separated with regard to the number of arms. Essentially, this separation was driven by the number of hydroxy groups that constituted the end group of each arm. Two-dimensional LC was used to show that the LCCC separation was exclusively driven by chemical composition irrespective of molar mass. 

Fig. 1.9 (A) Exfoliation of clay platelets (white Cloisite25A and Cloisite30B after (B) two and a arrows) in a commercial polylactide matrix using half months hydrolysis and (C) after five and a a masterbatch process. (B, C) Visual aspect half months hydrolysis. (A) adapted from [144] of unfilled PLA, microcomposite based on reproduced by permission ofWiley-VCH, and CloisiteNa+, and nanocomposites based on (B, C) from [147] with permission from Elsevier.

Jensen et al. reported the stereoselective polymerization of D,L-lactide with dibenzyloxidezinc(2,4,6-trimetylphe-nyimidazol-2-ylidene), which was synthesized as shown in Scheme 39.100 Surprisingly, a mixture of the heterocarbene and benzyl alcohol was a better catalyst for polylactide formation than the zinc complex, and unlike 50 the mixture produced heterotactically enriched polylactide. 

Chisholm et al. synthesized organozinc compounds with bulky biphenolates as catalysts for the ring-opening polymerization of lactides.196 The protonolysis of diethyzinc by the biphenols, in the presence of diisopropylmethanol, afforded the polycyclic, trimetallic zinc-di(ethylzinc) pre-catalyst 135, which polymerizes /m -lactide to polylactide, enriched in isi- and. sir-tetrads (Scheme 85). 

Kanchan V, Panda AK (2007) Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response. Biomaterials 28 5344-5357... 

Arimura H, Ohya Y, Ouchi T (2005) Formation of core-shell type biodegradable polymeric micelles from amphiphilic poly(aspartic acid)-Wock-polylactide diblock copolymer. Biomacromolecules 6 720-725... 

Fig. 5 Synthesis of polylactide-grafted polysaccharide (Dex-g-PLA) by trimethylsilyl-protection method...

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