Polylactide copolymers

M. Spinu, L-D polylactide copolymers with controlled morphology, US Patent 5270400, assigned to Maria Spinu, December 14,1993. 

Figure 1 1h NMR spectra (CDCI3) of polylactide copolymers with 6 mol% feed ratio (a) PLSl, and (b) PLS2.

R., and Runt, J. (2001) Crystallization and solid-state structure of random polylactide copolymers poly(L-lactide-co-D-lactide)s. Macromolecules, 34, 4857-4864. 

Bigg D.M. Polylactide copolymers effect of copolymer ratio and end capping on their properties, Adv. Polym. Sci. 24 (2005) 69. 

Alternatively, block polymers may be prepared by the sequential polymerization of two monomers using a bifunctional initiator, as exemplified by the preparation of diblock peptide-polylactide copolymers. tert-Butoxycarbonylaminopropanol is first engaged in the zinc-promoted ROP of lactide and, after deprotection of the terminal amine chain-end, the polyamide block is obtained by ROP of the N-carboxyanhydride (NCA) derived from y-benzyl glutamate (Scheme 10.15) [63], Such diblock peptide-polylactide copolymers also have interesting self-assembling properties [63]. 

The use of polylactides for delivery of insect hormone analogs and other veterinary compounds (115,116) has been studied. Microspheres, pellets, and reservoir devices based on polyglycolide, poly-(DL-Iactide), poly(L-lactide), and various copolymers have been used to deliver methoprene and a number of juvenile hormone analogs. ... 

Arimura H, Ohya Y, Ouchi T (2005) Formation of core-shell type biodegradable polymeric micelles from amphiphilic poly(aspartic acid)-Wock-polylactide diblock copolymer. Biomacromolecules 6 720-725... 

Bioerodible polymers offer a unique combination of properties that can be tailored to suit nearly any controlled drug delivery application. By far the most common bioerodible polymers employed for biomedical applications are polyesters and polyethers (e.g., polyethylene glycol), polylactide, polyglycolide and their copolymers). These polymers are biocompatible, have good mechanical properties, and have been used in... 

Figure 6 (Top) General structure of Polyphosphoesters. R and R can be varied to obtain polymers with varied physicochemical properties ranging from gels, to elastomers, to amorphous polymer particles. (Bottom) Example structure of a polylactide-co-ethylphosphate copolymer.

---