Polylactide/polyglycolide

Bioerodible polymers offer a unique combination of properties that can be tailored to suit nearly any controlled drug delivery application. By far the most common bioerodible polymers employed for biomedical applications are polyesters and polyethers (e.g., polyethylene glycol), polylactide, polyglycolide and their copolymers). These polymers are biocompatible, have good mechanical properties, and have been used in... 

Recent Developments in Metal-Catalyzed Ring-Opening Polymerization of Lactides and Glycolides Preparation of Polylactides, Polyglycolide, and Poly(lactide-co-glycolide). 219... 

Cleland, J.L. Design and production of single-immunization vaccines using polylactide polyglycolide micro-sphere systems. In Vaccine Design The Subunit and Adjuvant Approach Powell, M.F., Newman, M.J., Eds. Plenum Press New York, 1995 439 62. 

Martin C, Winet H, Bao JY. Acidity near eroding polylactide-polyglycolide in vitro and in vivo in rabbit tibial bone chambers. Biomaterials 17(24) 2373-2380, 1996. 

Polymeric micropsheres, particularly those prepared from the biodegradable polylactide/ polyglycolide polymers, have been widely investigated as a means to achieve sustained parenteral drug delivery. The advantage of formulating the polymeric matrix as microspheres is the ability to administer them via a conventional needle and syringe as a suspension formulation, rather than as an implant (see below). Lupron depot formulations are available which can provide therapeutic blood levels of leuprolide acetate for up to four months. These products are presented as lyophilized polylactic acid microspheres which are reconstituted to form a suspension prior to administration. 

J. Nieuwenhuis, Synthesis of Polylactides, Polyglycolides and Their Copolymers. Clinical Materials, Vol. 10, p. 59-67,1992. 

Winet, H. and Hollinger, J.O., 1993. Incorporation of polylactide-polyglycolide in a cortical defect neoosteogenesis in a bone chamber. /. Biomed. Mater. Res., TJ. 667-676. 

Nieuwenhuis, J., 1992, Synthesis of polylactides, polyglycolides and their copolymers, Clin. Mater. 10 59-67. 

Polylactide-polyglycolide (PLGA) [223] Vancomycin, gentamicin, lidocaine Electrospun sandwich-structured as nanofibrous membranes Biomimetic nanofibrous extracellular membranes for long-term drug delivery... 

Another group of polymers that have attracted increasing attention for their use as tissue engineering scaffolds in the last decade are degradable polymers, in particular polyesters (e.g. polylactide, polyglycolide), proteins and polysaccharides. 

Sutures Collagen, polylactide, polyglycolide, Mono-filament,... 

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