Polylactic-<?0-glycolic acid

Schwope, A.D. Wise, D.L. Howes, J.F. Development of polylactic/glycolic acid delivery systems for use in treatment of narcotic addiction. NIDA Research Monograph 1976, 4, 13-18. 

Table 4 A Partial List of Marketed Drug Delivery Products Utilizing Polylactic Acid or Poly(lactic-co-glycolic) Acid Polymers...

Abbreviations PLA, polylactic acid PLGA, poly(lactic-co-glycolic) acid. 

Container closure systems required for implantable devices are further restricted by the fact that they are required to be compatible with the formulation over the intended shelf life and therapeutic application time as well as being biocompatible. This means that the system not only must afford protection to and contain the formulation but also cannot cause any potential adverse effects, such as allergy. Typically, implantable systems are composed of biocompatible metals, such as titanium or polymers such as polyethylene glycol or polylactic-co-glycolic acid. 

Ogawa, Y., Yamamoto, M., Okada, H., Yashiki, T., and Shimamoto, T. (1988), A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid, Chem. Pharm. Bull., 36,1095-1103. 

Amphiphilic block copolymers consisting of polylactic acid or poly(lactic acid-h-glycolic acid) terminated with tocopherol or cholesterol were prepared by Seo [1] and used as drug delivery agents for Paclitaxel . 

Lupron Depot Injection is lyophilized microspheres of gelatin and glycolic-lactic acid for intramuscular (IM) injection. Nutropin Depot consists of polylactate-glycolate microspheres. 

BSA = bovine serum albumin PLA = polylactic acid PLGA = poly(lactic-co-glycolic acid) PEG = poly(ethylene glycol) PPG = poly(propylen Extraction temperature/pressure. 

Note DL-PLG Dl-poly(lacfic-co-glycolic acid) DL-PIA DL-polylactic acid L-PLA L-polylactic acid PGA polyglycolic acid PCL poly-e-caprolacfone. 

There is an increasing trend to consider nanoparticles as part of other delivery systems to create what are in effect hybrid systems. Dendrimers and dendrons can thus be found as particles in emulsions or vesicles. Macromolecular-dendrimer complexes (dendriplexes) may be incorporated in polylactic-co-glycolic acid (PLGA) nanoparticles (105). Dendrimers may also be grafted to linear polymers (as shown in Fig. 20). 

Abbreviations ASES, aerosol solvent extraction system BSA, bovine serum albumin PCA, precipitation with compressed antisolvent PLA, polylactic acid PLGA poly(lactic-co-glycolic acid) PMMA, poly(methyl methacrylate) PPG, poly(propylene glycol) RESS, rapid expansion of supercritical solution TFE, 2,2,2-trifluoroethanol. 

Abbreviations A, acetone ASES, aerosol solvent extraction system DM, dichloromethane DMF, A/,A/-dimethyl-formamide E, ethanol GAS, gas antisolvent process H, hexane HYAFF-11, hyaluronic acid benzylic ester I, isopropanol PAN, polyacrylonitrile PCA, precipitation with compressed antisolvent PCL, polycaprolactone PHB, poly(p-hydroxybutyric acid) PLA, polylactic acid PLGA, poly(lactic-co-glycolic acid) SAS, supercritical antisolvent process SEDS, solution enhanced dispersion by supercritical fluids TFE, 2,2,2-trifluoroethanol Triblock polymer, p poly(L-lactide-CO-D,L-lactide-co-glycolide)(62.5 1 2.5 25). 

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