Supercritical antisolvent process

Wang Y, Pfeffer R, Dave R. Polymer encapsulation of fine particles by a supercritical antisolvent process. 

Werling, J.O. Debenedetti, P.G. Numerical modeling of mass transfer in the supercritical antisolvent process miscible conditions. J. Supercrit. Fluids 2000, 18, 11-24. 

Yeo SD, Debenedetti PG, Radosz M, Schmidt HW. Supercritical antisolvent process for substituted para-linked aromatic polyamides phase equilibrium and morphology study. Macromolecules 1993 26 6207-6210. 

Table 4 Polymeric Microparticles Prepared by Using Supercritical Antisolvent Processes... 

Abbreviations A, acetone ASES, aerosol solvent extraction system DM, dichloromethane DMF, A/,A/-dimethyl-formamide E, ethanol GAS, gas antisolvent process H, hexane HYAFF-11, hyaluronic acid benzylic ester I, isopropanol PAN, polyacrylonitrile PCA, precipitation with compressed antisolvent PCL, polycaprolactone PHB, poly(p-hydroxybutyric acid) PLA, polylactic acid PLGA, poly(lactic-co-glycolic acid) SAS, supercritical antisolvent process SEDS, solution enhanced dispersion by supercritical fluids TFE, 2,2,2-trifluoroethanol Triblock polymer, p poly(L-lactide-CO-D,L-lactide-co-glycolide)(62.5 1 2.5 25). 

In the literature there is no agreement about nomenclature concerning gas and supercritical antisolvent processes (the most recent proposal is by Bungert et al. [26]). Therefore, they are classified here by the mode of operation ... 

WAN Wang, Y., Pfeffer, R., Dave, R., and Enick, R., Polymer encapsulation of fine particles by a supercritical antisolvent process, AIChE-J., 51, 440, 2005. 

Zhang, J., Huang, Y., Liu, D., Gao, Y., and Qian, S. Preparation of apigenin nanocrystals using supercritical antisolvent process for dissolution and bioavailability enhancement. European Journal of Pharmaceutical Sciences 48 (2013) 740-747. 

Montes, A., Nunes, A., Gordillo, M.D., Pereyra, C., Duarte, C.M.M., and Martmez de la Ossa, E.J. Amoxicillin and ethyl cellulose precipitation by two supercritical antisolvent processes. Chemical Engineering and Technology 36 (2013) 665-672. 

Visentin, A., Rodrfguez-Rojo, S., Navarrete, A., Maestri, D., and Cocero, M.J. Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent process. Journal of Food Engineering 109 (2012) 9-15. 

Guha, R., Vinjamur, M., and Mukhopadhyay, M. Demonstration of mechanisms for coprecipitation and encapsulation by supercritical antisolvent process. Industrial and Engineering Chemistry Research, 50 (2011) 1079-1088. 

Uzun, i.N., Sipahigil, O., and Dinner, S. Coprecipitation of cefuroxime Axetil-PVP composite microparticles by batch supercritical antisolvent process. The Journal of Supercritical Fluids 55 (2011) ... 

A supercritical fluid can be used as the external phase of a nanoprecipitation process. In this case, the method is named supercritical antisolvent processing" green tea polyphenols have been encapsulated in a biodegradable polylactide-PCL copolymer by a supercritical antisolvent process. ... 

Yeo, S.-D., Debenedetti, P.G., Radosz, M. and Schmidt, H.-W. (1993) Supercritical Antisolvent Process for Substituted Para-linked Aromatic Polyamides Phase Equilibrium and Morphology Study. Macromolecules 26,6207,... 

J. O. Werling and P. G. Debenedetti, Mass transfer and phase equilibria in the supercritical antisolvent process... 

The SAS methods have been used for preparing a variety of particles and fine powders from proteins, pharmaceuticals, pigments, polymers, and even explosives. For example, Debenedetti and coworkers used a continuous-flow, supercritical antisolvent process to prepare fine powders of trypsin, lysozyme, and insulin proteins (58-60). In the preparation a protein solution in dimethyl-sulfoxide (DMSO) was sprayed through a small orifice into supercritical CO2. The particles had diameters ranging from 1 to 5 p,m. The biological activity of the micrometer-sized powders was nearly the same as that of the starting materials. The method has also been used in the processing of pharmaceutically important compounds, such as salmeterol xinafoate (61), sulfathiazole (62), and methylprednisolone and hydrocortisone acetate (41). Kitamura et al. used the... 

Two different solutes with distinct properties were examined for the use in the supercritical antisolvent process. Next to the tailored micronization also the solubility of some of them in SAS-like systems was investigated. An active pharmaceutical ingredient (API) and a biopolymer were used. 

Dowy, S., Braeuer, A., Schatz, R., Schluecker, E., Leipertz, A. (2009). CO2 partial density distribution during high-pressure mixing with ethanol in the supercritical antisolvent process. Journal of Supercritical Fluids, 48, 195-202. 

De Marco, I., Prosapio, V., Cice, F., Reverchon, E. (2013). Use of solvent mixtures in supercritical antisolvent process to modify precipitates morphology Cellulose acetate microparticles. The Journal of Supercritical Fluids, 83, 153-160. 

Supercritical Antisolvent Process as Green Alternative in Polymer Optimization... 

R. Bettini, R. Menabeni, R. Tozzi, M. B. Pranzo, I. Pasquali, M. R. Chierotti, R. Gobetto, L. Pellegrino, Didanosine Polymorphism in a Supercritical Antisolvent Process, Journal of Pharmaceutical Sciences 99 (2010), p. 1855-1870. 

Srinivasan Shanmugama, Jae-Hyun Parka, Sang-Cheol Chi, Chul Soon Yong, Han-Gon Choi, Jong Soo Woo, Antitumor efficacy of solid dispersion of paclitaxel prepared by supercritical antisolvent process in human mammary tumor xenografts. International Journal of Pharmaceutics AQ3 (2011), p. 130-135. 

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