Poly acid PLGA

Fu, K., Pack, D.W., Klibanov, A.M., and Langer, R. (2000). Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharmaceut. Res., 17, 100-106. 

Early development of polymers in injectable drug delivery primarily involved PLA and poly(lactic-co-glycolic) acid (PLGA) due to the prior use of these polymers in biomedical applications as sutures. Besides the safe and biocompatible nature of these polymers, their ease of availability made them ideal first candidates for screening parenteral CR formulations. Some of the early biodegradable polymer-based products for injectable sustained release used these polymers. However because... 

Abbreviations PLA, polylactic acid PLGA, poly(lactic-co-glycolic) acid. 

When the core is an oily liquid, the surrounding polymer is a single layer of polymer, and the vesicle is referred to as a nanocapsule. These systems have found utility in the encapsulation and delivery of hydrophobic drugs Polymers used for the formation of nanocapsules have typically included polyester homopolymers such as poly(D,L-lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA) and poly(caprolactone) PCL [112],... 

Cultures of primary cardiac myocytes (chick embryo) were formed on fibronectin patterned acrylic surfaces [198]. A microtextured PDMS chip with 20-urn-wide pegs was used to promote cell culture. After coating the PDMS chip with a thin layer of laminin, neonatal rat cardiac myocytes were cultured on it. The cultured cells are typically 50 p.m in length and 10-15 p.m in diameter. The PDMS chip was cast on a mold with parylene structures patterned on a Si wafer. Using the same mold, a poly(lactic/glycolic acid) (PLGA) chip could also be made for culture of rat cardiac fibroblasts [900]. 

Polyesters, such as poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA), are examples of biomaterials that are degraded by homogeneous bulk erosion. 

Poly(lactic acid-co-glycolic acid) (PLGA Birmingham Polymers, Inc.) protect from moisture. 

Poly(lactic-co-glycolic acid (PLGA) microparticles HBsAg Strong systemic and mucosal immune responses 226... 

Spray desolvation involves spraying a polymer solution onto a desolvating liquid. For example, microparticles can be made by spraying a PVA solution onto an acetone bath. Here, the polymer solvent (water) is extracted into acetone, and PVA precipitates to form solid micro-particles.f In another example, bovine serum albumin (BSA) was encapsulated in poly(lactic-co-glycolic acid) (PLGA) by this method. The micronized drug was suspended in a PLGA-acetone solution and atomized ultrasonically into ethanol bath. ° ... 

BSA = bovine serum albumin PLA = polylactic acid PLGA = poly(lactic-co-glycolic acid) PEG = poly(ethylene glycol) PPG = poly(propylen Extraction temperature/pressure. 

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