PLGA polylactic acid-glycolic

The most commonly used polymers in drug formulations include polyesters (such as poly(lactic-co-glycolic acid) (PLGA), polylactic acid, polyglycolic acid, and poly(c-caprolactone)), polyanhydrides (such as poly(sebacic... 

Adapted from G. Ledet and T.K. Mandal, US Pharmacist, 2012, 37, 3, Oncology supplement, 7-11. ESA - Erythropoietic-stimulating agents HIV - Human immunodeficiency virus PLGA - Polylactic-co-glycolic acid TNF - Tumor necrosis factor VEGF - Vascular endothelial growth factor ... 

Abbreviations PLA, polylactic acid PLGA, poly(lactic-co-glycolic) acid. 

BSA = bovine serum albumin PLA = polylactic acid PLGA = poly(lactic-co-glycolic acid) PEG = poly(ethylene glycol) PPG = poly(propylen Extraction temperature/pressure. 

There is an increasing trend to consider nanoparticles as part of other delivery systems to create what are in effect hybrid systems. Dendrimers and dendrons can thus be found as particles in emulsions or vesicles. Macromolecular-dendrimer complexes (dendriplexes) may be incorporated in polylactic-co-glycolic acid (PLGA) nanoparticles (105). Dendrimers may also be grafted to linear polymers (as shown in Fig. 20). 

Abbreviations ASES, aerosol solvent extraction system BSA, bovine serum albumin PCA, precipitation with compressed antisolvent PLA, polylactic acid PLGA poly(lactic-co-glycolic acid) PMMA, poly(methyl methacrylate) PPG, poly(propylene glycol) RESS, rapid expansion of supercritical solution TFE, 2,2,2-trifluoroethanol. 

Abbreviations A, acetone ASES, aerosol solvent extraction system DM, dichloromethane DMF, A/,A/-dimethyl-formamide E, ethanol GAS, gas antisolvent process H, hexane HYAFF-11, hyaluronic acid benzylic ester I, isopropanol PAN, polyacrylonitrile PCA, precipitation with compressed antisolvent PCL, polycaprolactone PHB, poly(p-hydroxybutyric acid) PLA, polylactic acid PLGA, poly(lactic-co-glycolic acid) SAS, supercritical antisolvent process SEDS, solution enhanced dispersion by supercritical fluids TFE, 2,2,2-trifluoroethanol Triblock polymer, p poly(L-lactide-CO-D,L-lactide-co-glycolide)(62.5 1 2.5 25). 

From the perspective of biocompatibility, degradability, and process-ability, synthetic polymers have many advantages over complex natural polymers such as collagen. One class of polymers in particular, polyesters in the family of polylactic acid (PLA), polyglycolic acid (PGA), and copolymers of lactic and glycolic acids (PLGAs), most closely meets the listed criteria. These polymers have been approved by the FDA for in vivo... 

Encapsulated into polylactic-co-glycolic acid (PLGA) matrix HUVEC Encapsulated porous sihcon particles not taken up by cells when encapsulated in PLGA. Released dmg is taken up by cells Fan etal. (2012)... 

Although several synthetic polymers have been reported to be electrospun successfully and tested with different animal cells, not all of them were approved by FDA as safe biomaterials for biomedical applications. The most commonly known ones are polylactic acid (PLA), polyglycolic acid (PGA), and their copolymer polylactic-co-glycolic acid (PLGA) (Teo and Ramakrishna 2006). 

---