Drug delivery agents

Natural nontoxic and biodegradable polysaccharides (e.g., pullulan, pachyman, chito-san) have recently been developed as drug delivery agents, including nanoparticles and hydrogels that allow for controlled drug release from the matrix, thus improving the therapeutic effects. 

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Liu, M., Kono, K., and Frechet, J.M.J. (2000) Water-soluble dendritic unimolecular micelles their potential as drug delivery agents./. Contr. Release 65, 121-131. 

Fig. 13. The generation of multivalent penicillin derivatives by ROMP. It is proposed that such materials may function as drug delivery agents...

Singh, B. (2007). Psyllium as therapeutic and drug delivery agent. Int. ]. Pharm. 334,1-14. 

Darbre T, Reymond J-L. Peptide dendrimers as artificial enzymes, receptors, and drug-delivery agents. Acc Chem Res 2006 39 925-934. 

Absorbable polyoxaesters containing pendant thio substituents, (IV), were prepared by the authors (4) and used in tissue engineering scaffolds and as drug delivery agents. 

Elastomeric biodegradable copolyester amides, (IV), and copolyester urethanes were prepared by Chu et al. (4) and were effective as drug delivery agents. 

Lebovitz (1) and Hirsch et al. (2) prepared water-soluble dendritic fullerenes, which were used to oxidize reduced proteins and as drug delivery agents, respectively. 

Copolyesters prepared by Chen et al. (4) by the bulk polymerization of (V-acetyl-e-caprolactone, (II), with 1,8-octanediol using tin octanate were used as a biodegradable drug delivery agents. 

Dendrimers are a special class of arborescent monodisperse nanometer sized molecules that have been used in the synthesis of Au NPs as surface stabilizers or nanoreactor/templates for nanoparticle growth. Moreover, these hybrid nanomaterials have great potential for application in different fields such as sensors, imaging in cells, electrooptical devices, catalysis, drug delivery agents, and so on. 

Recchia, J., et al. 1995. A semisynthetic Quillaja saponin as a drug delivery agent for aminoglycoside antibiotics. Pharm Res 12 1917. 

The experiments reviewed in Section 13.1 demonstrated in detail that LCM can be labeled with lipophilic fluorescent dye and still retain their tumor-targeting properties. Furthermore, these lipophilic-dye-labeled LCM were shown to become internalized by tumor cells both in vitro and in vivo. This tumor-targeting ability of dye-labeled LCM, and their in vivo persistence at the tumor site and/or within the tumor cell for many minutes, suggested a potential use of LCM as a targeted drug-delivery agent or vehicle (ref. 532). Thus, a search was started for lipophilic anticancer drugs (preferably already FDA-approved for clinical use) that could be incorporated into the LCM and carried specifically to the tumor site. 

W/O microemulsions have been used in the preparation of nanopartides and for carrying out other reactions in highly confined geometries [234], As mentioned in Section 14.3 both nanoparticle suspensions and nanoemulsions have developed for use as drug-delivery agents. 

The oxazolidinone-based compounds are the most common (Figure 23.1), and examples include antibacterial,27-28 adhesion receptor antagonists,29-30 tumor necrosis factor inhibitors,31 platelet aggregation inhibitors,32 antimigraine drugs,33 and monoamine oxidase inhibitors.3435 In one case, an oxazolidinone has been used as a transdermal drug delivery agent.36... 

Tuning the properties of each generation to complement those of particular guest molecules makes it possible to bind those guests and then let them dissociate at a known rate. This controlled release property makes dendrimers potential candidates as drug delivery agents as illustrated in Fig. 7.8 [23],... 

Shalaby [2] prepared ionic molecular conjugates of the hydrolyzed drug delivery agent chitosan and Somatuline , (11), in the treatment of acromegaly. 

Amphiphilic block copolymers consisting of polyethylene glycol and poly-lactide, (I), were prepared by Seo [1] and used as drug delivery agents for Paclitaxel . 

Wang [3] prepared the amphiphilic biocompatible cyclodextrin graft polymer, poly(ethylene glycol-g-cyclodextrin), (III), containing modified cyclodextrin which was used as a bioactive drug delivery agent. 

Oh [7] prepared biodegradable lactide derivatives, (III), for conjugation with biologically active agents for use as drug delivery agents. 

Acrylic acid and derivatives have been free radically grafted onto the backbone of biodegradable polycaprolactone and poly(lactic-co-glycolic acid). These functionalized biocompatible materials are useful as drug delivery agents. 

III), formed a hydrogel that could be used to encapsulate water-insoluble materials. Soybean-based materials prerpared by Liu [4] were also effective as hydrogels and used as drug delivery agents. 

Wang [1] prepared biocompatible cyclodextrin grafted polymers, (I), consisting of hydrophobically modified cyclodextrin with a biocompatible hydrophilic polymer backbone that were used as drug delivery agents. 

Nathan [4] prepared poly(monostearoyl glycerol-co-glyceryl monooleate-succinate), (IV), to prepare amphiphilic block polyester microdispersions that were bioabsorbable and biocompatible and useful as drug delivery agents. 

F.M. Monger, US Patent 5,391,726 (February 21, Assignee The Dow Chemical Company Utility Macrocyclic Lipids for Drug Delivery Agents... 

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