Poliovirus against

Active immunization against poliovirus Rare malaise, nausea, diarrhea, fever Three doses 0.5 mL PO at specified intervals... 

Vaccine diphtheria and tetanus toxoids and acellular pertussis adsorbed, hepatitis B (recombinant) and inactivated poliovirus combined Pediarix Active immunization against diphtheria, tetanus, pertussis and all known subtypes of hepatitis B virus, and poliomyelitis immunization Sfee adverse reactions against individual vaccines. Primary immunization series 3 doses of 0.5 mLat 6-to 8-week intervals IM (first dose is 2 months of age, but may be given as early as 6 weeks of age)... 

The structure/activity relationships for the methisazone, 3a, derivatives against adenoviruses and poxviruses have been shown to be similar [78]. Pearson and Zimmerman [79] demonstrated that all three types of polioviruses are inhibited by 2-acetylpyridine JV-dibutylthiosemicarbazone, which is similar to 3a, by blocking viral RNA synthesis. A 3-substituted triazinoindole derivative of isatin was effective against several strains of rhinovirus in tissue culture the mechanism of action is unknown [80]. 

Z0339 Kurokawa, M., H. Ochiai, K. Naga-saka, et al. Antiviral traditional medicines against herpes simplex (HSV-1), poliovirus, and measles virus in vitro and their therapeutic efficacies for HSV-1 infection in mice. Antiviral Res 1993 22(2/3) 175-188. 

Crotty, S., C.J. Miller, B.L. Lohman, M.R. Neagu, L. Compton, D. Lu, F.X. Lu, L. Fritts, ID. Lifson, and R. Andino, Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors. J Virol, 2001. 75(16) 7435-52. 

Poliovirus, type 1 ethanol activity against [DISINFECTANTS AND ANTISEPTICS] (Vol 8)... 

The future importance of peptide vaccines lies in the fact that one could replace inactivated or attenuated microbial pathogens or toxins, which are high-molecular and therefore difficult to characterize and standardize, by highly specific synthetic peptides. Emini et al.157 have synthesized oligopeptides that prime the rabbit immune system and are effective against poliovirus. The amino acid sequence of the peptide vaccines 63 and 64 originate in the poliovirus VPt protein. 

In the first studies, antibodies were used to elucidate the dynamic nature of poliovirus [51]. Antibodies were raised against peptides representing VP4 and the N termini of VPl. In the crystal structures of all of the picornaviruses, these termini lie at the capsid-RNA interface and are therefore not exposed to external solvent [27, 46, 52-55]. These antibodies bound to the virus when the particles were heated to 37°C but did not bind when added to virus at room temperature or when the virus was heated to 37°G and then cooled to room temperature. Therefore, although difficult to visualize with the static structure of the capsid, the only explanation for these results is that these buried termini are transiently exposed. This exposure is facilitated by higher temperatures and was proposed to be part of the normal infection process. This idea of dynamic capsid structures was subsequently supported by mass spectroscopy analysis of flock house virus [56] and rhinovirus [57] and by a series of drug—poliovirus structures [58]. 

Vaccination programmes have been very effective in the control of some viral diseases. Protection against smallpox was first demonstrated in 1796 by Jenner by inoculation with cowpox. Smallpox was later successfully eradicated. Poliovirus is also being eliminated thanks to a controlled intensive worldwide vaccination programme initiated by the World Health Organization. Such preventative methods are the most effective and economic way of controlling viral infections. 

The hot water extracts of bulbs and leaves of Haemanthus albiflos had strong antiviral activity against Poliovirus 1, Herpes simplex 1 virus. Vesicular stomatitis vims and simian Rotavirus SA11 (100, 101). The bulbs of this species also showed strong antiviral activity against Moloney murine leukemia virus and HIV(i02). 

Tnorpholonluin quaternary compounds have been shown to be active In mice Infected with mouse hepatitis and herpes simplex viruses.vfe n cell culture, N -furfurylblquanlde was active against a variety of RNA viruses.— A lengthy report on the effect of salicylates on EMC virus In cell culture Is not completely convlnclngV Certaln derivatives of it-oxo-5 thlazoll-dlne are claimed to have a wide antiviral spectrum but only data for poliovirus inhibition are presented.V ... 

As polysaccharide vaccines were shown to elicit only limited protection in infants and young children, conjugated polysaccharide vaccines were developed to provide a more potent and sustained immune response [2]. Many of these traditional vaccines target childhood diseases, and are used in combinations for pediatric applications in order to reduce the number of injections during the first years of life. Currently, vaccine combinations can prevent against between three to six different diseases, such as the measles-mumps-rubella (MMR) vaccine or the diphtheria-tetanus-pertussis combination, which may be administered together with Haemophilus influenzae, hepatitis B, or poliovirus vac-... 

Poliovirus vaccine, live, oral, trivalent, is a live virus vaccine that induces protective antibodies, reducing intestinal and pharyngeal excretion of poliovirus. OPV administration simulates natural infection, inducing active mucosal and systemic immunity against poliovirus types 1, 2, and 3. 

Natural quinones also exert antiviral activity against other viruses, such as the Epstein-Barr virus and poliovirus type 2 and 3 [163-165], For example, chrysophanic acid (l,8-dihydroxy-3-methylanthraquinone) isolated from the Australian Aboriginal medicinal plant Dianella longifolia Street has been found to inhibit the replication of poliovirus type 2 and 3 in vitro. Four structurally-related anthraquinones (rhein, Fig. (5), 1,8-... 

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