Pick s disease

Pickling agent Pickling of steel Pickling solutions Pick s disease Pidoram [1918-02-1]... 

Uncomplicated, with delirium, with delusions, and with depressed mood Dementia due to HIV disease Dementia due to head trauma Dementia due to Parkinson s disease Dementia due to Huntington s disease Dementia due to Pick s disease Dementia due to Creutzfeldt-Jakob disease Dementia due to a specific general medical condition (specify) Dementia that is substance-induced Dementia due to multiple etiologies Dementia not otherwise specified... 

CBD) Pick s disease Frontotemporal regions 3R tau NF Paired helical formation, NFT... 

McKhann, G. M., Albert, M. S., Grossman, M. et al. Clinical and pathological diagnosis of frontotemporal dementia report of the Work Group on Frontotemporal Dementia and Pick s Disease. Arch. Neurol. 58 1803-1809, 2001. 

They include progressive supranuclear palsy, corticobasal degeneration and Pick s disease 753... 

TABLE 45-2 Tau diseases Alzheimer s disease Down s syndrome Progressive supranuclear palsy Corticobasal degeneration Pick s disease Argyrophilic grain disease Tangle-only dementia... 

The study of FTDP-17 has established that dysfunction or misregulation of tau protein can cause neurodegeneration and dementia. It follows that tau protein is probably also of central importance in the pathogenesis of diseases, such as Alzheimer s disease, progressive supranuclear palsy, corticobasal degeneration and Pick s disease. This is further underlined by the fact that the aforementioned diseases are partially or completely phenocopied by cases of FTDP-17. 

Zinc is important to the normal functioning of the central nervous system (CNS). At low concentrations, zinc protects mammalian brain neurons by blocking N-methyl-D-aspartate receptor-mediated toxicity. At high concentrations, zinc is a potent, rapidly acting neurotoxicant in the mammalian brain, as judged by zinc-induced neuronal injury of in vitro mature cortical cell cultures (Choi et al. 1988). Increased brain levels of zinc are associated with Pick s disease in certain strains of rodents with inherited epileptic seizures. Intravenous injection of zinc in rats with genetically inherited epilepsy produces seizures a similar response occurs with intracranial injection of zinc in rabbits with inherited audiogenic seizures (Choi et al. 1988). 

Frontotemporal dementia involves an early and primary degenerative process of frontal and/or temporal cortex. Several disorders fall under this rubric, such as Pick s disease and the dementia associated with amyotrophic lateral sclerosis (ALS). ALS is a degenerative disease of upper motor neurons that is sometimes accompanied by a frontal lobe dementia (Vercelletto et al. 1999 Abe et al. 1997). ALS has been associated with mutations in the free radical scavenging enzyme superoxide dismutase 1 (Price et al. 1997). Pick s disease is associated histologically with a loss of neurons and cytoplasmic Pick bodies in surviving neurons. 

The cause of Alzheimer s disease is unknown, but genetic factors clearly play a role. One clue supporting this view is provided by the observation that individuals with Down syndrome, a common cause of mental retardation, frequently develop a dementia similar to Alzheimer s disease during early adulthood. Vascular dementia, which is also called multi-infarct dementia, results from the accumulation of tiny strokes. Individually, these strokes or infarcts are too small to cause any noticeable problem, but as they accumulate, they produce deficits similar to Alzheimer s disease. Other neurological diseases such as Parkinson s disease, Pick s disease, and Huntington s disease cause slow deterioration of the brain that ultimately leads to a degenerative dementia. 

Dementias due to trauma usually do not progress in this manner. The injury damages the brain and causes dementia, but further deterioration does not occur. In contrast, a few dementias can be rapidly progressive. This includes most dementias due to infection (although syphilis and AlDS-related dementias are usually slowly progressive) as well as Pick s disease, a dementia associated with a relatively early age of onset, characterized by massive degeneration of frontal and temporal lobe tissue. 

Research continues in an effort to gain a more thorough understanding of how lipoproteins arc synthesized how lipids are arranged and combined with proteins to form cell membranes what specific role lipids play in transport across cell membranes how hormones act to regulate lipid metabolism, the biochemical basis of such abnormal lipid metabolic states as Gaucher s disease. Nieniann-Pick s disease, etc. how lipids per sc permeate cell membranes anil huw many phenotypic lipoproteins occur in serum. 

Meier-Ruge, W., Iwangoff, P., Reichlmeier, K. Neurochemical enzyme changes in Alzheimer s and Pick s disease. Arch. Gerontol. Geriatr. 1984, 3 161-165. 

Pick s disease is a rare neurodegenerative disease which causes progressive destruction of nerve cells in the brain and causes tau proteins to accumulate into Pick bodies , which are a defining characteristic of the disease. 

Pick s disease Difficult to distinguish clinically from Alzheimer s disease at times slowly progressive dementia hyperoral behavior disinhibition irritability persistent aimless wandering memory loss language difficulties frontal lobe atrophy seen on brain imaging diagnosed at autopsy by Pick bodies in neurons. 

In addition to phosphorylation, tau is also subjected to ubiquitinylation. Ubiquitin is a 76 amino acid protein that flags the proteins to be degraded in an ATP-dependent manner. Ubiquinated tau has been found in inclusion bodies found in Pick s disease or Parkinson s disease or in PHFs in AD. 

Pick s disease Multiple system Guam type C... 

Tolnay and Probst, 1999). Among the tauopathies, the most studied is AD. The analyses of other types of dementia with tau pathology have usually been performed in comparison with AD (Spillantini and Goedert, 2000). Based on electtophoretic pattern, several classes of tau aggregation are presently described. (1) AD and Parkinsonism dementia complex (six tau isoforms) (2) PSP and CBD (three isoforms with exon 10 corresponding sequence) (3) Pick s disease (PiD) (three isoforms without exon 10), and (4) myotonic dystrophy-the shortest tau isoform (Caparros-Lefebvre et al., 2002). 

Morris HR, Baker M, Yasojima K, Houlden H, Khan MN, Wood NW, et al. (2002) Analysis of tau haplotypes in Pick s disease. Neurology 59 443-445 Morris HR, Lees Al, Wood NW (1999) Neurofibrillary tangle parkinsonian disorders-tau pathology and tau genetics. Mov Disord 14 731-736... 

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