Phosphorylation of histones

Phosphorylation of histone HI is associated with the condensation of chromosomes during the replication cycle. [Pg.315]

Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, et al. Phosphorylation of histone H2AX and activation of Mrell, Rad50, and Nbsl in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J. Biol. Chem. 2003 May 30 278(22) 20303-12. [Pg.96]

The phosphorylation of histone HI has been reviewed several times in recent years (Dixon et al., 1975 Elgin and Weintraub, 1975 Gurley et al., 1978 Langan, 1978 Isenberg, 1978). Therefore, we will not give a full discussion of the subject here. Only points relevant to HI-DNA interaction will be mentioned. [Pg.34]

Karymov MA, Tomschik M, Leuba SH, Caiafa P, Zlatanova J (2001) DNA methylation-dependent chromatin fiber compaction in vivo and in vitro requirement for hnker histone. Faseb J 15 2631—2641 Kaszas E, Cande WZ (2000) Phosphorylation of histone H3 is correlated with changes in the maintenance of sister chromatid cohesion during meiosis in maize, rather than the condensation of the chromatin. J Cell Sci 113(Pt 18) 3217-3226... [Pg.25]

Wei Y, Mizzen CA, Cook RG, Gorovsky MA, Allis CD (1998) Phosphorylation of histone H3 at serine 10 is correlated with chromosome condensation during mitosis and meiosis in Tetrahymena. Proc Natl Acad Sci U S A 95 7480-7484... [Pg.29]

Figure 4. Histone modification cross-talk between phosphorylation of histone H3 (SIO) and acetylation of histone H3 (K14) or methylation of histone H3 (K9). Histone H3 phoshorylation at SIO can enhance acetylation of histone H3 at K14 (Cheung et at, 2000), (Lo et at, 2000). (b) Histone H3 phoshorylation at SIO abolish acetylation of histone H3 at K9 (Edmondson et at, 2002). (c) Histone H3 phoshorylation at SIO inhibits methylation of histone H3 at K9 (Rea et at, 2000). (d) methylation of histone H3 at K9 interferes with phosphorylation of histone H3 at SIO. Phosphorylation is represented by the blue flag, acetylation is represented by the black flag, and methylation represented by the green flag...

We have discussed phosphorylation of histone H3, which has been studied in many organisms. Phosphorylation of histone H3 (SIO) has two opposite main functions. One is necessary to initiate chromosome condensation during mitosis and meiosis, while the other is transcriptional activation. Current evidence shows that a combination of phosphorylation of H3 (SIO) and methylation of H3 (K9) or acetylation H3 (K9, K14) play important roles in these phenomena including cell cycle related chromosome dynamics and transcriptional activation. These results suggest that a combination of different histone modifications excute different biological outcomes. [Pg.327]

Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen CA, Beeser A, Etkin LD, Chernoff J, Earnshaw WC, AlUs CD (2003) Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 113(4) 507-517... [Pg.330]

Contreras A, Hale TK, Stenoien DL, Rosen JM, Mancini MA, Herrera RE (2003) The dynamic mobility of histone HI is regulated by cyclin/CDK phosphorylation. Mol Cell Biol 23(23) 8626-8636 Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis CD, Sassone-Corsi P (2002) Mitotic phosphorylation of histone H3 spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol 22(3) 874-885... [Pg.331]

Eernandez-Capetillo O, Allis CD, Nussenzweig A (2004) Phosphorylation of histone H2B at DNA double-strand breaks. J Exp Med 199(12) 1671—1677 Eernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A (2002) DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol 4(12) 993-997... [Pg.331]

Hendzel MJ, Wei Y, Mancini MA, Van Hooser A, Ranalh T, Brinkley BR, Bazett-Jones DP, Allis CD (1997) Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106(6) 348—360... [Pg.332]

Nowak SJ, Corces VG (2000) Phosphorylation of histone H3 correlates with transcriptionally active loci. Genes Dev 14(23) 3003-3013... [Pg.333]

Ota T, Suto S, Katayama H, Han ZB, Suzuki F, Maeda M, Tanino M, Terada Y, Tatsuka M (2002) Increased mitotic phosphorylation of histone H3 attributable to AIM-l/Aurora-B overexpression contributes to chromosome number instability. Cancer Res 62(18) 5168-5177 Paulson JR, Taylor SS (1982) Phosphorylation of histones 1 and 3 and nonhistone high mobihty group 14 by an endogenous kinase in HeLa metaphase chromosomes. J Biol Chem 257(11) 6064—6072 Petersen J, Paris J, Wilier M, Philippe M, Hagan IM (2001) The S. pombe aurora-related kinase Arkl associates with mitotic structures in a stage dependent manner and is required for chromosome segregation. J Cell Sci 114(Pt 24) 4371 384... [Pg.334]

Polioudaki H, Markaki Y, Kourmouli N, Dialynas G, Theodoropoulos PA, Singh PB, Georgatos SD (2004) Mitotic phosphorylation of histone H3 at threonine 3. FEBS Lett 560(l-3) 39 4 Preuss U, Landsberg G, Scheidtmann KH (2003) Novel mitosis-specific phosphorylation of histone H3 at Thrll mediated by Dlk/ZIP kinase. Nucleic Acids Res 31(3) 878-885 Prigent C, Dimitrov S (2003) Phosphorylation of serine 10 in histone H3, what for J Cell Sci 116(Pt 18) 3677-3685... [Pg.334]

Sassone-Corsi P, Mizzen CA, Cheung P, Crosio C, Monaco L, Jacquot S, Hanauer A, Allis CD (1999) Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science 285(5429) 886-891... [Pg.334]

Taylor WR, Chadee DN, Allis CD, Wright JA, Davie JR (1995) Fibroblasts transformed by combinations of ras, myc and mutant p53 exhibit increased phosphorylation of histone HI that is independent of... [Pg.335]

Utley RT, Lacoste N, Jobin-Robitaille O, Allard S, Cote J (2005) Regulation of NuA4 histone acetyl-transferase activity in transcription and DNA repair by phosphorylation of histone H4. Mol Cell Biol 25(18) 8179-8190... [Pg.335]

Wei Y, Yu L, Bowen J, Gorovsky MA, Allis CD (1999) Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Cell 97(1) 99—109 Wyatt HR, Liaw H, Green GR, Lustig AJ (2003) Multiple roles for Saccharomyces cerevisiae histone H2A in telomere position effect, Spt phenotypes and double-strand-break repair. Genetics 164(l) 47-64... [Pg.336]

ZeitUn SG, Shelby RD, Sullivan KF (2001) CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J Cell Biol 155(7) 1147-1157 Zhang Y, Griffin K, Mondal N, Parvin JD (2004) Phosphorylation of histone H2A inhibits transcription on chromatin templates. J Biol Chem 279(21) 21866-21872... [Pg.336]

Mishra S, Saleh A, Espino PS, Davie JR, Murphy LJ (2006) Phosphorylation of histones by tissue transglutaminase. J Biol Chem 281 5532-5538... [Pg.425]

It has recently been shown that some phosphorylations may be useful only to activate a protein and once in its active form or complexed, phosphorylation is no longer needed (Scheme 3). Karwowska-Desaulniers et ak recently hypothesized that phosphorylation of histone deacetylase 1 (HDACl) at two key residues is important for complex formation of active protein in vivo. However, when the phosphorylation sites were mutated to alanine, no active protein was expressed, yet complex formation was still observed. Even when native protein was expressed and dephosphorylated, complex formation and activity were still observed. The complex formation is still not fully understood the complexes are thought to place HDAC in the correct position. No active noncomplexed HDAC has been generated in order to study the effects of complexation. Interestingly, when HDACl was expressed in bacteria and subsequently phosphorylated there was no... [Pg.436]

The results obtained from the histone acetylation and phosphorylation studies suggest that cyclo(Trp-Trp) and cyclo(Pro-Trp) induce differential gene expression through different signal transduction pathways. Cyclo(Trp-Trp) induced the highest level of acetylation of histones whereas cyclo(Phe-Pro) induced high levels of phosphorylation of histones." ... [Pg.685]

Kleinschmidt, J.A. and Steinbeisser, H. (1991) DNA-dependent phosphorylation of histone H2A.X during nucleosome assembly in Xenopus laevis oocytes involvement of protein phosphorylation in nucleosome spacing. EMBO J. 10, 3043-3050. [Pg.204]

Fig. 4. Phosphorylation of histone HI, H3, and CENP-A throughout the cell cycle.

As morusin (3) was assumed to interact with the phorbol ester receptor, we examined whether it inhibited the activation of protein kinase C by teleocidin in vitro [73]. Fig. (9) shows that morusin (3) inhibited the phosphorylation of histone type III-S by protein kinase C dose-dependent and that 80 pmol/L morusin caused 50% inhibition. [Pg.213]

Fujikati, J.M. Fung, G. Oh, E.Y. Smith, R.A. Characterization of chemical and enzymatic acid-labile phosphorylation of histone H4 using phosphorus-31 nuclear magnetic resonance. Biochemistry, 20, 3658-3664 (1981)... [Pg.428]

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