Nucleosome assembly

The structure of the nucleosome is affected by ionic environment. The low ion concentration makes a nucleosomal array well spread whereas 100 mM NaCl induces nucleosome-nucleosome interaction (Hizume et al, 2005 Nakai et al, 2005 Olins and Olins, 1972 Thoma et al, 1979). In vitro transcription system has been applied to understand the relationship between the nucleosome assembly and transcription activity. The results demonstrated that a positive super-coiling introduced during the progress of RNA polymerase makes the nucleosomes ahead of the polymerase unstable (Pfaffle et al, 1990). [Pg.12]

Akey CW, Luger K (2003) Histone chaperones and nucleosome assembly. Curr Opin Struct Biol 13 6-14 Aoyagi S, Hayes JJ (2002) hSWI/SNF-catalyzed nucleosome sliding does not occur solely via a twist-diffusion mechanism. Mol Cell Biol 22 7484—7490... [Pg.40]

Henikoff S, Furuyama T, Ahmad K (2004) Histone variants, nucleosome assembly and epigenetic inheritance. Trends Genet 20 320-326... [Pg.86]

Tagami H, Ray-Gallet D, Almouzni G, Nakatani Y (2004) Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell 116 51-61 Taneja N, Davis M, Choy JS, Beckett MA, Singh R, Kron SJ, Weichselbaum RR (2004) Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy. J Biol Chem 279 2273-2280... [Pg.88]

Ahmad K, Henikoff S (2002) The histone variant H3.3 marks active chromatin by repUcation-independent nucleosome assembly. Mol Cell 9 1191—1200... [Pg.105]

Kleinschmidt J.A, Seiter A Zentgraf H (1990) Nucleosome assembly in vitro separate histone transfer and synergistic interaction of native histone complexes purified from nuclei of Xenopus laevis oocytes. EMBO J 9 1309-1318... [Pg.123]

Sakaguchi K, Herrera JE, Saito S, Mild T, Bustin M, Vassilev A, Anderson CW, Appella E (1998) DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev 12( 18) 2831-2841 Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB (2000). Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. Mol Cell Biol 20(23) 8933-8943... [Pg.211]

Ito T (2003) Nucleosome assembly and remodehng. Curr Top Microbiol Immunol 274 1-22 Ito T, Tyler JK, Kadonaga JT (1997) Chromatin assembly factors a dual function in nucleosome formation and mobilization Genes Cells 2(10) 593-600 Ivanovska I, Khandan T, Ito T, Orr-Weaver TL (2005) A histone code in meiosis the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes. Genes Dev 19(21) 2571-2582... [Pg.332]

Even in 1978, it was realized the assembly of nucleosomes in vivo was likely to be a facilitated process. In fact, Laskey et al. [33] had discovered a factor, nucleo-plasmin that assisted in this assembly. Very recently. X-ray diffraction studies have revealed much about this protein, and its probable role in nucleosome assembly [34] or disassembly [35]. At the same time, single-molecule studies (see Zlatanova and Leuba, this volume, p. 369) have provided an insight into the dynamics and energetics of nucleosome formation. This appears likely to be an area in which rapid progress is possible. [Pg.4]

In addition to a potential role of HMGB proteins in nucleosome assembly, it has recently become apparent that many chromatin remodeling complexes either contain, or can associate with, a polypeptide containing an HMG-box homologous to the HMGBl B domain (Table 2). Examples of such complexes include the BAF (a mammalian SWI/SNF related complex [106]) and the Drosophila BRM (brahma)... [Pg.115]

Bonne-Andrea, C., Harper, F., Sobczak, J., and de Recondo, A.M. (1984) Rat liver HMGl a physiological nucleosome assembly factor. EMBO J. 3, 1193-1199. [Pg.129]

Waga, S., Mizuno, S., and Yoshida, M. (1989) Nonhistone proteins HMGl and HMG2 suppress the nucleosome assembly at physiological ionic strength. Biochim. Biophys. Acta 1007, 209-214. [Pg.129]

Fan, Z., Beresford, P.J., Zhang, D., and Lieberman, J. (2002) HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol. Cell Biol. 22, 2810-2820. [Pg.130]

Shikama, N., Chan, H.M., Krstic-Demonacos, M., Smith, L., Lee, C.W., Cairns, W., and La Thangue, N.B. (2000) Functional interaction between nucleosome assembly proteins and p300/ CREB-binding protein family coactivators. Mol. Cell. Biol. 20, 8933-8943. [Pg.130]

Kleinschmidt, J.A. and Steinbeisser, H. (1991) DNA-dependent phosphorylation of histone H2A.X during nucleosome assembly in Xenopus laevis oocytes involvement of protein phosphorylation in nucleosome spacing. EMBO J. 10, 3043-3050. [Pg.204]

The recent reconstitution of CENP-A containing nucleosomes confirms the ability of these histones to form nucleosome assemblies in specialized chromatin domains [66] although the stability and structure of these nucleosome particles remain to be defined. At first glance, the dynamic nature of centromeres during chromosome motility suggests that CENP-A may contribute to enhance the... [Pg.247]

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