Phosphocholine

Fig. 1. Chemical stmcture of phosphatidylcholine (PC) (1) and other related phosphohpids. R C O represents fatty acid residues. The choline fragment may be replaced by other moieties such as ethanolamine (2) to give phosphatidylethanolamine (PE), inositol (3) to give phosphatidylinositol (PI), serine (4), or glycerol (5). IfH replaces choline, the compound is phosphatidic acid (6). The corresponding lUPAC-lUB names ate (1), l,2-diacyl-t -glyceto(3)phosphocholine (2), l,2-diacyl-t -glyceto(3)phosphoethanolamine (3), 1,2-diacyl-t -glyceto(3)phosphoinositol (4), 1,2-diacyl-t -glyceto(3)phospho-L-serine and (5), l,2-diacyl-t -glyceto(3)phospho(3)-t -glycetol.

Supported lipid bilayers on planar silicon substrates have been formed using S-layer protein from B. coagulans E38/vl and from B. sphaericus CCM 2177 as support onto which l,2-dimyristoyl-OT-glycero-3-phosphocholine (DMPC) (pure or mixtures with 30% cholesterol) or DPPC bilayers were deposited by the Langmuir-Blodgett-technique (Pig. 

AGEPC l-O-alkyl-2-acetyl-iw-glyceryl-3-phosphocholine also known as PAF and APRL AH Acetylhydrolase AID Autoimmune disease AIDS Acquired immune deficiency syndrome... 

Crilly, K.S., Tomono, M. and Kiss, Z. (1998) The choline kinase inhibitor hemicholinium-3 can inhibit mitogen-induced DNA synthesis independent of its effect on phosphocholine formation. Archives of Biochemistry and Biophysics 352, 137-143. 

Haslam, S.M., Houston, K.M., Harnett, W., Reason, A.J., Morris, H.R. and Dell, A. (1999) Structural studies of phosphocholine-substituted IV-glycans of filarial parasites conservation amongst species and discovery of novel chito-oligomers. Journal of Biological Chemistry 274, 20953-20960. 

Wuhrer, M., Rickhoff, S., Dennis, R.D., Lochnit, G., Soboslay, P.T., Baumeister, S. and Geyer, R. (2000) Phosphocholine-containing, zwitterionic glycosphingo-lipids of adult Onchocerca volvulus as highly conserved antigenic structures of parasitic nematodes. BiochemicalJournal 348, 417-423. 

In positive ion mode, the characteristic peaks representative of the binding media were fatty acids from lead soaps (of palmitic acid at m/z 461 463 and of stearic acid at m/z 489 491). Other peaks corresponding to mono- and diacylglycerol cations, protonated stearic acid or its acylium ions could be found in the spectra of the reference products but not in the paint sample. The spectrum of lead white egg tempera paint exhibits peaks of phosphocholine (m/z 184) and protonated ketocholesterol (m/z 401). These peaks were not found in the spectrum from the cross-section. In negative ion mode, the spectrum of the oil... 

Recently, a series of soluble phospholipids with n-hexanoyl side chains and a variety of headgroups were assayed as substrates for PLCBc [37]. The results (Table 4) indicate that both l,2-dihexanoyl-s -glycero-3-phosphocholine (C6PC) and l,2-dihexanoyl-sn-glycero-3-phosphoethanolamine (C6PE) are processed with similar catalytic efficiencies (kcaXIKm) by the enzyme, while 1,2-dihe-... 

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