2-dipalmitoyl-sn-glycero-3-phosphocholine

R-l,2-Dipalmitoyl-sn-glycero-3-phosphocholine monohydrate (dipalmitoyl-a-L-Iecithin) [63-89-8] M 752.1, sinters at 120°, [a]p +7.0° (c 5.6, abs CHCI3). It has three crystn forms aj, a2 and p which change at 60-70° and at 229° respectively. In order to obtain a fine powder, -2 g are dissolved in CHCI3 (15ml) and pet ether (b 35-60°) is added and the soln evaporated to dryness in vacuo <20°, and then dried at 0.1mm over CaCl2. [Baer and Maurukas JACS 74 158 1952 Baer and Kates JBC 185 615 1950]. 

R-l,2-Dipalmitoyl-sn-glycero-3-phosphocholine monohydrate (dipalmitoyl-a-L-lecithin)... 

Cameron, D. G., Casal, H. L. and Mantsch, H. H. Characterization of the pretransition in l,2-dipalmitoyl-sn-glycero-3-phosphocholine by Fourier transform infrared spectroscopy. Biochemistry 79 3665-3672, 1980. 

Fully hydrated samples of dipalmitoylphosphatidylcholine (DPPC, 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine), the lipid used in the first studies with synchrotron radition show a series of three well-defined transitions in the temperature range between 15 and 45 °C which are termed sub- (around 17 °C), pre- (around 33 °Q and main transition (41,4 °C) for a detailed investigation of the static X-ray diffraction behaviour of this system, see Refs. The underlying structures are schematically depicted in Figure 6a. The transition parameters, temperature and enthalpies, are constant only above a limiting value of full hydration (25 moles H O per mol DPPC, i.e. approximately 38 weight- % H O), and are sensitive also to the ionic environment. 

Figure 181. Effect of membrane components on the leakage of 5-fluorouracil from liposomes during storage at 4°C. O, LW (PC/PS/CH 7 4 5) A, LUV (MC/PS/CH 7 4 5) O, MLV (PC/PS/CH 7 4 5). LW, Large unilamellar vesicle, PC, l,2-dipalmitoyl-sn-glycero-3-phosphocholine monohydrate, PS, dipalmitoyl-DL-C phosphatidyl-L-serine, CH, cholesterol, MC, l,2-dimyristoyl-sn-glycero-3-phosphocholine monohydrate, MLV, multilamellar vesicle. (Reproduced from Ref. 717 with permission.)...

The following abbreviations will be used for the phospholipids. POPC, l-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine DLPC, 1,2-dilauroyl-sn-glycero-3-phosphocholine DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine DPPC, l,2-dipalmitoyl-sn-glycero-3-phosphocholine... 

FIGURE 3.19 DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine), a saturated phospholipid and the primary component of lung surfactant. 

DOPE l,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DPPC l,2-Dipalmitoyl-SM-glycero-3-phosphocholine DPPS l,2-Dipalmitoyl-s -glycero-3-phosphoserine LB Langmuir-Blodgett MC Monte Carlo... 

Dilauroyl-sn-glycero(3) phosphocholine 1,2-Dipalmitoyl-sn-glycero(3) phosphatidylcholine 1,2-Distearoyl-sn-glycero(3) phosphatidylcholine ipotropic drug Betaine Choline chloride ipstick... 

Fig. 15 Upper. DC PC (l,2-bis(trideca-12-ynoyl)-sn-glycero-3-phosphocholine). Reprinted with permission from [102]. Copyright 2001, Elsevier. Lower DPPE-DVBA (1,2-dipalmitoyl- -glycero-3-phospho-7V-(2-hydroxyethyl)-3,5-divinylbenzamide). Reprinted with permission from [103]. Copyright 2003, American Chemical Society...

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