Dimyristoyl-glycero-3-phosphocholine DMPC

Supported lipid bilayers on planar silicon substrates have been formed using S-layer protein from B. coagulans E38/vl and from B. sphaericus CCM 2177 as support onto which l,2-dimyristoyl-OT-glycero-3-phosphocholine (DMPC) (pure or mixtures with 30% cholesterol) or DPPC bilayers were deposited by the Langmuir-Blodgett-technique (Pig. 

Fig. 6 Structure of membrane components (a) dioctadecyldimethylammonium bromide, (b) 1,2-dimyristoyl, s7i-glycero-3-phosphocholine (DMPC), (c) 1,2-dilauroyl, S7i-glycero-3-phospho-choline (DLPC), (d) dicetyl phosphate (DCP)...

The lipids l,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dipal-mitoyl-sn-glycero-3-phosphocholine (DPPC), and l,2-dilauroyl-5 -glycero-3-phosphocholine (DLPC), were obtained from Avanti Polar Lipids (Alabaster, AL) and used without further purification. Three types of samples were investigated ... 

In addition to the long-chain fatty acid molecules described above, a large number of studies have appeared that use IRRAS to study phospholipid monolayers as models of biomembrane interfaces. Mitchell and Dluhy [26] reported the first IRRAS spectra of 1,2-distearoyl-5 -glycero-3-phosphocholine (DSPC), l,2-dimyristoyl-i -glycero-3-phosphocholine (DMPC), and 1,2-di-palmitoyl-,v/ -glycero-3-phosphocholine (DPPC) monolayers at the air-water... 

Figure 2.9 In situ STM imaging of l,2-dimyristoyl-sr)-glycero-3-phosphocholine (DMPC) lipid membranes. Molecular structures of the membrane constituents (a) DM PC (b) cholesterol, (c) DM PC...

The following abbreviations will be used for the phospholipids. POPC, l-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine DLPC, 1,2-dilauroyl-sn-glycero-3-phosphocholine DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine DPPC, l,2-dipalmitoyl-sn-glycero-3-phosphocholine... 

Electrochemistry may also be used to probe the interactions between ferrocifens and nonpolar molecular architectures, with respect to the hydrophobic architectures/barriers that compose ceU membranes as well as lipidic cargoes/vectors (e.g., liposomes) using model systems consisting of glassy carbon electrodes modified with a planar bilayer of 1,2-dimyristoyl-OT-glycero-3-phosphocholine (DMPC) (Fig. 47.20) [56]. 

The interaction between bacterial lipopolysaccharides (EPS) and phospholipid cell membranes was studied by various physical methods of deep rough mutant EPS (ReEPS) of Escherichia coH incorporated in phospholipid bilayers as simple models of cell membranes. SS P-NMR spectroscopic analysis suggested that a substantial part of ReEPS is incorporated into l,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayers when mixed multilamellar vesicles were prepared. Furthermore the lipid lateral diffusion coefficients measurements at various molar ratios of ReEPS/egg-PC/POPG indicated that the incorporated ReEPS reduces the diffusion coefficients of the phospholipids in the membrane. EUV formed by the ReEPS from Salmonella enterica, eventually in mixture with dilauroyl phosphatidylcholine (DEPC), have been prepared and characterized by DES, SANS and EPR. PFGSE NMR measurements have shown that water permeability through the lipid bilayer is low at room temperature. However, above a transition temperature centered at 30-35 °C, the water permeability increases. ... 

Transmission electron microscopy investigations performed on freeze-etching replicas of lipid vesicles of l,2-dimyristoyl-OT-glycero-3-phosphocholine (DMPC)... 

The same cholestane nitroxide probe has been recently utilized by Mangels et al to study alignment of mixed l,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and l,2-dihexanoyl-5n-glycero-3-phosphocholine (DHPC) bicelles at 3.4 T magnetic field of W-band EPR." These studies demonstrated that the order parameter for cholestane in DMPC/DHPC bicelles containing 10% cholesterol is S = 0.64 + 0.04 which is very similar to that determined for mechanically aligned bilayers. 

CAS 18194-24-6 13699-48-4 EINECS/ELINCS 242-085-9 Synonyms 1,2-Dimyristoyl phosphatidylcholine 1,2-Ditetradecanoyl-sn-glycero-3-phosphocholine DMPC 3-sn-Phosphatidylcholine-1,2-dimyristoyl Classification Phospholipid Empirical C35H72NO8P... 

An example of how the procedure works is shown in Figure 18.5. The peptide in this example is MSI-103, which has been labeled with 19F at the four positions indicated in Figure 18.5a. Four different peptides were synthesized where a single amino acid (Ala-7, Ile-9, Ala-10, or Ile-13) was replaced with CF3-Phg. For each label a 19F NMR spectrum is recorded (see Figure 18.5a) in this example, spectra are from MSI-103 in DMPC (1,2-dimyristoyl-OT-glycero-3-phosphocholine) at a peptide-to-lipid molar ratio (P/L) = 1 400,... 

Figure 47.20 Schematic representation of the glassy carbon electrode (GCE) modified with DMPC film (l,2-dimyristoyl-rn-glycero-3-phosphocholine) used to investigate the interactions between ferrocifens with a model membrane.

DMPC l,2-dimyristoyl-sn-glycero-3-phosphocholine, multilamellar vesicle... 

---