CDP-choline 1,2-diacylglycerol phosphocholine

CMP + Phosphatidylcholine (catalyzed by CDP-Choline 1,2-Diacylglycerol Phosphocholine Transferase), , ... 

CDP-Choline 1,2-diacylglycerol phosphocholine transferase catalzyes the following reaction in the biosynthetic pathway leading to phosphatidylcholine (Figure 19.5)... 

Finally PC is made by releasing the CMP group in the process of fusing phosphocholine to diacylglycerol (DAG) by the enzyme CDP-choline 1,2-diacylglycerol choUnephosphotransferase (CPT McMaster and Bell, 1997). One cloned isoform of CPT seems specific for CDP-choUne, whereas another CPT also can synthesize PE from CDP-ethanolamine and DAG (Henneberry and McMaster, 1999 Heimeberry et al., 2000). 

Fig. 3. Regulation of PC biosynthesis via the CDP-choline pathway by modulation of the binding of CTP phosphocholine cytidylyltransferase (CT) to membranes. Three different modes of regulation of CT activity are indicated. The abbreviations are CK, choline kinase CPT, CDP-choline 1,2-diacylglycerol cholinephos-photransferase PEMT, phosphatidylethanolamine Af-methyltransferase PC, phosphatidylcholine PE, phos-phatidylethanolamine DG, diacylglycerol.

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