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Phosphocholine transferase

Phosphatidylcholine is synthesized via the Kennedy pathway (Kennedy and Weiss, 1956) in three consecutive steps catalyzed by the enzymes choline kinase, phosphocholine cytidyltransferase, and phosphocholine transferase. Phospha-tidylethanolamine is synthesized via the corresponding pathway for ethanolamine or by decarboxylation of phosphatidylserine (Borkenhagen et al., 1961) or by base exchange (Bjerve, 1973). In immobilized breast cancer cells, flux in these pathways... [Pg.259]

CTP phosphocholine cytidylyltransferase (3) glycerol kinase (4) acyl-CoA glycerol-3-phosphate acyltransferase (5) acyl-CoA acyl glycerol-3-phosphate acyltransferase (6) phosphatidic acid phosphatase (7) CDP-choline diacylglycerol phosphocholine transferase. [Pg.403]

CMP + Phosphatidylcholine (catalyzed by CDP-Choline 1,2-Diacylglycerol Phosphocholine Transferase), , ... [Pg.732]

CDP-Choline 1,2-diacylglycerol phosphocholine transferase catalzyes the following reaction in the biosynthetic pathway leading to phosphatidylcholine (Figure 19.5)... [Pg.1840]

These results are consistent with the incorporation of sulfocholine, as the CDP-sulfocholine derivative, into PSC by the phosphocholine transferase enzyme (Eq. 1). In both diatoms, the enzyme appears to have a higher affinity for choline than for sulfocholine and sulfocholine inhibits the incorporation of choline to about the same... [Pg.17]

This enzyme [EC 2.3.1.23], also called lysolecithin acyl-transferase and lysophosphatidylcholine acyltransferase, catalyzes the reaction of an acyl-CoA derivative with 1-acyl-5 n-glycero-3-phosphocholine to yield coenzyme A and l,2-diacyl-5 n-glycero-3-phosphocholine. The enzyme preferentially acts on unsaturated acyl-CoA derivatives, but l-acyl-5 n-glycero-3-phosphoinositol can also act as the acceptor. [Pg.30]

Synthesis of phosphatidylcholine and phosphatidylethanolamine begins with activation of choline (or ethanolamine) with ATP via choline kinase to yield phosphocholine (phosphoethanolamine) + ADP the activated base is transferred via CTP and phosphocholine cytidyl transferase to form CDP-choline (CDP-ethanolamine) and PPi. The base is then transferred to the sn-3 of diacylglycerol via phosphocholine diacylglycerol transferase to yield phosphatidylcholine (phosphatidylethanolamine) + CMP. The cytidyl transferase is believed to be the rate-limiting or regulatory step in the pathway. Phospha-tidylserine is formed by a direct transfer and substitution of serine for ethanolamine in phosphatidylethanolamine. Phosphatidyl serine can be dec-arboxylated to form phosphatidylethanolamine. [Pg.67]

Fig. 8. Biosynthesis of plasmenylcholine via the modification of the sn-2 acyl and sn-3 head-group moieties of plasmenylethanolamine. The reactions are catalyzed by the following enzymes (I) PLAj, (II) CoA-independent transacylase, (HI) lysophospholipase C, (IV) lysophospholipase D, (V) phosphotransferase, (VI) acyl-CoA acyl-transferase, (VII) phosphohydrolase, and/or (VIII) cholinephosphotransferase. Etn, ethanolamine Cho, choline GPE, s/i-glycero-3-phosphoethanolamine GPC, 5/i-glycero-3-phosphocholine. Fig. 8. Biosynthesis of plasmenylcholine via the modification of the sn-2 acyl and sn-3 head-group moieties of plasmenylethanolamine. The reactions are catalyzed by the following enzymes (I) PLAj, (II) CoA-independent transacylase, (HI) lysophospholipase C, (IV) lysophospholipase D, (V) phosphotransferase, (VI) acyl-CoA acyl-transferase, (VII) phosphohydrolase, and/or (VIII) cholinephosphotransferase. Etn, ethanolamine Cho, choline GPE, s/i-glycero-3-phosphoethanolamine GPC, 5/i-glycero-3-phosphocholine.
Phosphocholine + CTP <=> CDP-choline + PPi, (catalyzed by CTP phosphocholine cytidyl transferase)... [Pg.1687]

McKean, M.L., Smith, J.B. and Silver, M.J. (1982). Phospholipid biosynthesis in human platelets. Formation of phosphatidylcholine from 1-acyl-lysophosphatidylcholine by acyl-CoA l-acyl-sn-glycero-3-phosphocholine acyl transferase. ]. Biol Chem., 257, 11278-11283... [Pg.12]

See other pages where Phosphocholine transferase is mentioned: [Pg.441]    [Pg.313]    [Pg.1685]    [Pg.1840]    [Pg.41]    [Pg.46]    [Pg.15]    [Pg.618]    [Pg.441]    [Pg.313]    [Pg.1685]    [Pg.1840]    [Pg.41]    [Pg.46]    [Pg.15]    [Pg.618]    [Pg.524]    [Pg.1768]    [Pg.342]    [Pg.342]    [Pg.50]    [Pg.219]    [Pg.221]    [Pg.574]    [Pg.241]    [Pg.259]    [Pg.424]    [Pg.116]    [Pg.295]    [Pg.368]   
See also in sourсe #XX -- [ Pg.313 ]



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Phosphocholine

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