Taisho Pharmaceutical

Jpii Appl. Kokai 85-105679 (June 11, 1985), K. Mizogami, M. Yamagishi, S. Omuia, N. Otake, andH. Seto (to Taisho Pharmaceutical Co., Ltd.). 

The authors wish to thank the Green Cross Corporation, Taisho Pharmaceutical Co.,... 

Products/technologies In 1994, Eli Lilly felt they had secured a solid position in the field of combinatorial chemistry when they acquired Sphinx Pharmaceuticals, which Lilly viewed as having prominent achievements in this technology. In March 1997 the company signed a contract with Taisho Pharmaceutical Co. to introduce technology in the field of combinatorial chemistry, including the construction of a large-scale, diversified library of chemical compounds, and to efficiently synthesize derivatives. 

YOSHiRO KOHNO (327), Research Center, Taisho Pharmaceutical Company, Ltd., Saitama, Japan... 

There is only a small number of reports in the literature about the cytotoxicity of dimeric hydroxyanthracenones Toroasol I (28) and II (29) inhibit an in-vitro KB cell line with an ED50 of 1.7 and 5.5 pg/ml respectively occidentalol I (25a), occidentalol II (25b) and phlegmacines (21) have been patented as cytotoxic agents by Taisho pharmaceutical Co.[74] however, phlegmacines Aj and B, did not show selective toxicity. 

Takido, M Kitanaka, S. (Taisho Pharmaceutical), Chem Abst., 1989,110, 82474... 

JAP(K)4334378 M. Maruhashi, K. Hanada, K. Mizogami and A. Nagakura (Taisho Pharmaceutical Co. 

Patent filings from Taisho Pharmaceutical Co. had claimed already by 1990 a new and promising approach towards calcitriol via microbial (lS,25)-dihydrox-ylation of cholecalciferol. [105, 106] Nocardia autotrophica hydroxylates both positions, whereas Amycolata autotrophica, in contrast, shows a preference for mono-hydroxylation in the side-chain. 

Essex UK) and more recently with Pfizer Global Research Development (Groton, CT). CI-976 is also commercially available from Tocris Cookson Inc (Ellisville, MO) and Tocris Cookson Ltd (Bristol, UK) (Cat. No. 2227), and material from this source is active in our hands. However, we have not used material from this source. Other ACAT inhibitors were DuP-128 (GlaxoSmithKline) PFK 058 035 (Novartis, Summit, NJ), and TS-962 (Taisho Pharmaceutical Co., LTD, Tokyo, Japan). 

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