Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Human embryonic stem cells

Finally, lentiviral vectors have been shown to transduce human embryonic stem cells. Therefore, this type of gene-therapy vector might also be used in stem cell-based therapies. [Pg.532]

Xu C, Inokuma MS, Denham J, Golds K, Kundu P, Gold JD, Carpenter MK (2001) Feeder-free growth of undifferentiated human embryonic stem cells. Nat Biotechnol 19 971-974... [Pg.194]

Derda R, Li L, Omer BP, Lewis RL, Thomson JA, Kiessling LL (2007) Defined substrates for human embryonic stem cell growth identified from surface arrays. ACS Chem Biol 2 347-55... [Pg.198]

Ronaghi M, Erceg S, Moreno-Manzano V, Stojkovic M (2010) Challenges of stem cell therapy for spinal cord injury Human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells Stem Cells 28 93-99... [Pg.198]

Such cells are often classified on the basis of their original source as either embryonic or adult stem cells. As the name suggests, embryonic stem cells are derived from the early embryo, whereas adult stem cells are present in various tissues of the adult species. Much of the earlier work on embryonic stem cells was conducted using mouse embryos. Human embryonic stem cells were first isolated and cultured in the laboratory in 1998. Research on adult stem cells spans some four decades, with the discovery during the 1960s of haematopoietic stem cells in the bone marrow (Chapter 10). However, the exact distribution profile, role and ability to manipulate adult stem cells (particularly those outside of the bone marrow) are subjects of intense current research, and for which more questions remain than are answered. [Pg.457]

Culture of human embryonic stem cells starts with the recovery of the blastocyst s inner cell mass (Figure 14.17). One common recovery procedure is termed immunosurgery . The process... [Pg.457]

Figure 14.17 Overview of the generation and culture of human embryonic stem cells. IVF in vitro fertilization. Refer to text for further details... Figure 14.17 Overview of the generation and culture of human embryonic stem cells. IVF in vitro fertilization. Refer to text for further details...
Figure 14.18 Some cell types reported to have been produced via in vitro directed differentiation from either mouse or human embryonic stem cells. Potential uses for such cell types in regenerative medicines are listed in italics... Figure 14.18 Some cell types reported to have been produced via in vitro directed differentiation from either mouse or human embryonic stem cells. Potential uses for such cell types in regenerative medicines are listed in italics...
Human embryonic stem cells / Culture as floating aggregratesN. (embryoid bodies), forming / neuroepithelial cells s Culture to form midbrain dopamine neurons ... [Pg.459]

Figure 14.19 Simplified schematic overview of the directed differentiation of human embryonic stem cells to form differentiated dopamine like neurons. The full pathway details are available in Yan, Y., Yang, D., Zarnowska, E.D., Du, Z., Werbel, B., Valliere, C., etai 2005. Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells 23, 781-790. FGF fibroblast growth factor SHH sonic hedgehog (a regulatory protein)... Figure 14.19 Simplified schematic overview of the directed differentiation of human embryonic stem cells to form differentiated dopamine like neurons. The full pathway details are available in Yan, Y., Yang, D., Zarnowska, E.D., Du, Z., Werbel, B., Valliere, C., etai 2005. Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells 23, 781-790. FGF fibroblast growth factor SHH sonic hedgehog (a regulatory protein)...
Hoffman, L. and Carpenter, M. 2005. Characterization and culture of human embryonic stem cells. Nature Biotechnology 23(6), 699-708. [Pg.463]

Gerecht S, Burdick JA, Ferreira LS, Townsend SA, Langer R, Vunjak-Novakovic G (2007) Hyaluronic acid hydrogen for controlled self-renewal and differentiation of human embryonic stem cells. Proc Natl Acad Sci USA 104 11298-11303. [Pg.309]

Levenberg S, Huang NF, Lavik E, Rogers AB, Itskovitz-Eldor J, Langer R (2003) Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci USA 100 12741-12746. [Pg.311]

Xu et al. [76] have showed that human embryonic stem cells by treatment with bone morphogenetic protein-4 can be driven to differentiate into tro-phoblasts which have the ability to syncytialize and form confluent mono-layers. The differentiated cells express a number of trophoblast markers and secrete placental hormones and thus may provide an alternative placental model. Under the culture conditions used, however, the cells propagated poorly. [Pg.377]

HUMAN EMBRYONIC STEM CELLS CAN MODEL EMERGING ANGIO-HEMATOPOIESIS... [Pg.141]

Zambidis ET, Peault B, Park TS, Bunz F and Civin Cl (2005). Hematopoietic differentiation of human embryonic stem cells progresses through sequential hemato endothelial, primitive, and definitive stages resembling human yolk sac development. Blood 106 860-870. [Pg.147]

Products manufactured or tested using human embryos or human embryonic stem cells... [Pg.668]

Phanstiel, D. et al. (2008) Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 105, 4093 098. [Pg.18]

Otte, A.P., Volkert, T.L., Bartel, D.P., Melton, D.A., Gifford, D.K., Jaenisch, R. and Young, R.A. (2006) Control of developmental regulators by Polycomb in human embryonic stem cells. Cell,... [Pg.158]

Anderson DG, Levenberg S, Langer R (2004) Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat Biotech 22 863-866... [Pg.15]

Itskovitz-Eldor J, Schuldiner M, Karsenti D, Eden A, Yanuka O, Amit M, Soreq H, Benvenisty N. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Mo/MeJ 2000 6 88-95. [Pg.124]

Cardiotoxicity Assessment of human cardiotoxicity potential - human embryonic stem cell derived cardiomyocytes and ion and membrane potential dyes (also neurotoxicity, nephrotoxicity, myelotoxicity potential)... [Pg.341]

Research on human embryonic stem cells and therapeutic cloning... [Pg.118]

Think about your beliefs on the issue of human embryonic stem cells. Do you support their use What kind of laws should we have in place to regulate the work Where would the possibility of cures for devastating illness like Parkinson s disease fit into your consideration ... [Pg.119]

Korean scientists report human embryonic stem cell produced using a nucleus from an adult cell... [Pg.148]

Gerecht-Nir, S., and J. Itskovitz-Eldor. The Promise of Human Embryonic Stem Cells. Best Practice Research Clinical Obstetrics Gynaecology 18 no. 6 (2004) 843-852. [Pg.165]

Kleinstreuer NC et al (2011) Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics. Toxicol Appl Pharmacol 257 111-121... [Pg.94]

The EST has continued to be a popular test subject to further optimization, especially through the addition of alternative pathways of differentiation and the addition of molecular markers of effects. Besides cardiac muscle differentiation, other cell types such as neurons (29-31), osteoblasts (32), adipocytes (33), and hepato-cytes (34) have been generated in dedicated differentiation protocols, providing additional opportunities for testing the interference of differentiation pathways with chemical exposures. The addition of transcriptomics approaches to measure differential gene expression, both as influenced by the differentiation process as well as due to chemical exposure, has proven informative and may enhance the predictability of EST assays (35). The extension of this concept to human embryonic stem cell lines is still in its infancy, but has opened a new realm of options that bypasses the need for interspecies extrapolation (36). [Pg.331]

Kehat, I., D. Kenyagin-Karsenti, M. Snir, H. Segev, M. Amit, A. Gepstein, E. Livne, O. Binah, J. Itskovitz-Eldor, and L. Gepstein, Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest, 2001.108(3) 407-14. [Pg.412]

Muotri, A.R., Nakashima, K., Toni, N., Sandler, V.M., Gage, F.H. (2005). Development of functional human embryonic stem cell-derived neurons in mouse brain. Proc Natl Acad Sci, USA 102, 18644-8. [Pg.39]

Hurlbut, W.B. (2005). Altered nuclear transfer as a morally acceptable means for the procurement of human embryonic stem cells. Perspect Biol Med, 48, 211-28. [Pg.40]

See other pages where Human embryonic stem cells is mentioned: [Pg.214]    [Pg.458]    [Pg.458]    [Pg.458]    [Pg.511]    [Pg.286]    [Pg.391]    [Pg.348]    [Pg.141]    [Pg.144]    [Pg.668]    [Pg.6]    [Pg.338]    [Pg.245]    [Pg.402]    [Pg.411]   
See also in sourсe #XX -- [ Pg.668 ]

See also in sourсe #XX -- [ Pg.40 ]

See also in sourсe #XX -- [ Pg.11 , Pg.73 ]

See also in sourсe #XX -- [ Pg.531 ]

See also in sourсe #XX -- [ Pg.531 ]

See also in sourсe #XX -- [ Pg.152 ]



SEARCH



Cell-based therapies human embryonic stem cells

Embryon

Embryonic

Embryonic cells

Embryonic stem

Human embryonic stem cells . cell-based

Human embryonic stem cells, culture

Human stem cells

Mobile - Human Embryonic Stem Cells and Other Sources for Cell Therapy

Myocardial Regeneration Strategies using Human Embryonic Stem Cells

© 2024 chempedia.info