Peptide-based amphiphilic molecule

Self-assembly of short peptide derivates and peptide-based amphiphilic molecules... 

Self-Assembly of Short Peptide Derivates and Peptide-Based Amphiphilic Molecules... 

Peptide-Based Amphiphilic Molecules Peptide-based amphiphilic molecules can be divided into ... 

Recently, unique vesicle-forming (spherical bUayers that offer a hydrophilic reservoir, suitable for incorporation of water-soluble molecules, as well as hydrophobic wall that protects the loaded molecules from the external solution) setf-assembUng peptide-based amphiphilic block copolymers that mimic biological membranes have attracted great interest as polymersomes or functional polymersomes due to their new and promising applications in dmg delivery and artificial cells [ 122]. However, in all the cases the block copolymers formed are chemically dispersed and are often contaminated with homopolymer. 

Biological molecules do show regularity at the level that is not obtained with synthetic polymers. Protein folding is a perfect example, but it is not yet well understood. Therefore, protein-based 3D drug delivery systems are difficult to design. However, small peptides with amphiphilic structure (e.g., V6K, where six valines form hydrophobic part and lysine is the hydrophilic end group) can assemble... 

Table 2 Designer self-assembling systems based on peptide amphiphiles molecules. ...

Peptide amphiphiles Peptide-based molecules that self-assemble into nanofibers through the presence of hydrophilic peptide regions attached to hydrophobic alkyl tails. 

Li) and reverse (L2) curvatnre respectively, can be swollen by oil and water to form water/oil/amphiphile ternary or pseudo-ternary systems. These systems can be used for different types of studies, e.g. structural investigations of an immobilized peptide or protein, drug delivery systems, and also micellar catalysis. A variety of ternary systems based on water, oil, and amphiphile mixtures have been investigated. Thermodynamically stable microemulsions, e.g. Li or L2 monophasic regions, may form spontaneously provided that the amphiphilic molecules located at the polar-apolar interface cause a substantial decrease of the oil-water interfacial tension (Yo/w) according to the typical equation ... 

With the above-mentioned variety of addition reactions based on the addition-elimination mechanism almost any functional group or molecule can be attached to CgQ. Some examples are acetylenes [43, 52], peptides [53], DNA-fragments [53], polymers [54], macrocycles [55, 56], porphyrins [56, 57], dendrimers [58-60] or ligands for complex formation [56], Cjq can be turned into hybrids that are biologically active, water soluble, amphiphilic or mixable with polymers [53-55, 58, 61-69],... 

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