Paint/painting teratogenicity

Butyl acetate [123-86-4], one of the more important derivatives of -butyl alcohol produced commercially, is employed as a solvent in rapid drying paints and coatings. In some instances, butyl acetate, C.H1202, has replaced ethoxyethyl acetate [111-15-9] due to the latter s reported toxicity and teratogenicity. Butyl acetate is used in leather treatment, perfumes, and as a process or reaction solvent and is also used extensively with wood coatings, maintenance coatings, and in coatings for containers and closures. 

Specific teratogens were not identified, but as previously discussed in Sections 12.5 and 13.5, both waterborne paints and oil-based paints contain mixtures of lipophilic and hydrophilic species. Exposures to both types of paints have been associated with low level unexpected effects. Accordingly, the teratogenic results reported in the Dutch study are not surprising. 

Ethyl glycol acetate [111-15-9] (2-ethoxyethyl acetate) is a colorless, neutral liquid that is partially miscible with water and readily miscible with organic solvents. It has a slight odor. Ethyl glycol acetate dissolves many natural and synthetic resins. Cellulose acetate is swollen. Poly(vinyl chloride), rubber, and polyisobutene are insoluble. It is no longer used in paints due to its teratogenic properties. 

Methyl glycol [109-86-4] (2-methoxyethanol, ethylene glycol monomethyl ether) has a slight odor, and is miscible with water and organic solvents except aliphatic hydrocarbons. It is a very good solvent for many natural and synthetic resins. It does not dissolve fats, oils (except castor oil), damar resin, rubber, bitumen, hydrocarbon resins, polystyrene, poly(vinyl chloride), and vinyl chloride copolymers. On account of its teratogenic properties it is replaced as a solvent in the paint and colorants sector by other solvents or solvent mixtures. 

Toxicology LD50 (oral, rat) 3100 mg/kg toxic hannful if swallowed may imtate skin experimental teratogen TSCA listed Uses Systemic fungicide for citms fmits preservative for paints preservative, fungicide in foods anthelmintic dmg antimicrobial in cosmetics... 

Major Applications corrosion inhibitor, 10.n disinfectant, cosmetics,2 paints toothpaste,mouthwash,4 antifungal agent, inhibit flbrosis, antituberculosis agent 4 Safety/Toxicity Toxicity, teratogenicity, acute oral toxicity ... 

Industrial Applications Adhesives " paints " inks " toners coloring cigarette papers, textiles Safety/Toxicity Carcinogenicity chronic toxicity clastogenic effects DNA repair embryotoxicity food allergy hepatotoxicity occupational asthma reproductive toxicity teratogenicity Certification/Approval Certified by Biological Stain Commission (BSC)... 

Toluene 700 Psychiatric change, cognitive dysfunction, fatigue, myopathy, nephrotoxicity, teratogen Gasoline, paints, adhesives, inks, solvents 0.13 pgA by GC with FID 6 pg/ 1 by GC-MS... 

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