Ethoxyethyl acetate

The liquid instilled in the eyes of animals caused immediate discomfort, some conjunctival irritation, and a slight transitory irritation of the cornea, which was readily reversible. Repeated and prolonged contact of the liquid with the skin of rabbits caused only a mild irritation, but toxic amounts were readily absorbed through the skin. 

Because EE is well absorbed through the skin, ambient monitoring of environmental exposure level is not considered to be an accurate method of determining absorbed dose. Biological monitoring of the ethoxyethanol metabolite 2-ethoxyacetic acid in urine has been shown to be an effective indicator of absorbed dose in workers.  

The 2003 ACGIH threshold limit valuetime-weighted average (TLV-TWA) for 2-ethoxyethanol is 5 ppm (18mg/m ) with a notation for skin absorption. 

Reproductive toxicity of ethylene glycol monoethyl ether tested by continuous breeding of CD-I mice. Environ Health Perspect 57 85-90, 1984 

Doe JE Eurther studies on the toxicology of the glycol ethers with emphasis on rapid screening and hazard assessment. Environ Health Perspect 57 199-206, 1984 

---

Methyl amyl ketone, derived from the crossed aldol condensation of -butyraldehyde and acetone, is used predominandy as a high soHds coatings solvent. It is also employed as a replacement for the very toxic 2-ethoxyethyl acetate [111 -15-9J. 

The (9-cresol novolaks of commercial significance possess degrees of polymerization, n, of 1.7—4.4 and the epoxide functionaUty of the resultant glycidylated resins varies from 2.7 to 5.4. Softening points (Durran s) of the products are 35—99°C. The glycidylated phenol and o-cresol—novolak resins are soluble in ketones, 2-ethoxyethyl acetate, and toluene solvents. The commercial epoxy novolak products possess a residual hydrolyzable chlorine content of <0.15 wt% and a total chlorine content of ca 0.6 wt % (Table 2). 

ETHOXYETHANOL (EGEE) and 2-ETHOXYETHYL ACETATE (EGEEA) 2-Ethoxyacetic acid in urine End of shift at end of workweek 100 mg/g creatinine ... 

Ethanol, 2-methoxy-, 62 Ethanolamines, 62 Ethmylestradiol, 62 Ethion, 62 Ethoprophos, 63 2-Ethoxyethanol, 63 2-Ethoxyethyl acetate, 63 Ethyl acetates, 63 Ethyl acetylene, 63... 

Ethoxyethanol 2-Ethoxyethyl acetate Ethyl acrylate Ethylene dinitrate 4-Ethylmorpholine 2-Furaldehyde Furfuryl alcohol Glycerol trinitrate Heptachlor... 

METHYL ISOBUTYL KETONE n-PENTYL FORMATE n-BUTYL ACETATE sec-BUTYL ACETATE tert-BUTYL ACETATE ETHYL n-BUTYRATE ETHYL ISOBUTYRATE ISOBUTYL ACETATE n-PROPYL PROPIONATE CYCLOHEXYL PEROXIDE DIACETONE ALCOHOL 2-ETHYL BUTYRIC ACID n-HEXANOIC ACID 2-ETHOXYETHYL ACETATE HYDROXYCAPROIC ACID PARALDEHYDE... 

ETHOXYETHYL ACETATE 1.9276 -3.1451E+03 5.7407E+00 -2.1017E-02 1.1834E-05 211 597... 

---