Oxidation therapy

Halliwell, B. and Gutteridge, J.M.C. (1984). Lipid peroxidation, oxygen radicals, cell damage and anti-oxidant therapy. Lancet i, 1396-1398. 

The use of corticosteroids is controversial. While they may decrease the inflammation and endothelial cell adhesion seen with ACS, their use also has been associated with higher readmission rates for other complications. Tapered corticosteroids, nitric oxide therapy, and L-arginine are being evaluated for use in ACS in studies.34,36... 

Griffiths MJ, Evans TW Inhaled nitric oxide therapy in adults. N Engl J Med 2005 353 2683. [PMID 16371634]... 

Kinsella JP, Abman SH. Inhaled nitric oxide therapy in children. Paediatr Respir Rev. 2005 6 190-198. 

Stephens N (1997). Anti-oxidant therapy for ischemic heart disease where do we stand Lancet 349 1710-1711... 

A native American woman developed a rise in methemoglobin from 0.9 to 9.4% over 6 hours of inhaled nitric oxide therapy, 80 ppm with reduction of the dose to 40 ppm, methemoglobin returned to basehne concentration. A patient who received inhaled nitric oxide through an imprecise delivery device had a methemoglobin concentration of 67%. Another patient who received a dose of 110 ppm had a methemoglobin concentration of 19%. 

Finer NN, Barrington KJ. Nitric oxide therapy for the newborn infant. Semin Perinatol 2000 24(l) 59-65. 

Clark RH, Kueser TJ, Walker MW, Southgate WM, Huckaby JL, Perez JA, Roy BJ, Keszler M, KinseUa JP. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group. N Engl J Med 2000 342(7) 469-74. 

Kilner RG, D Souza RJ, Oliveira DB, MacPhee IA,Turner DR, Eastwood JB. Acute renal failure from intoxication by Cortinarius orellanus recovery using anti-oxidant therapy and steroids. Nephrol Dial Transplant 1999 14 2779-2780... 

This is going to be a singular presentation of a case of multiple sclerosis which was, in our experience, most unusual. The treatment that we had administered was that of oxidative therapy (H202 intravenously). 

Multiple Sclerosis is a disease of unknown etiology or therapy. The article brought up the other day in the newspaper stating that there may have been established a viral etiology for multiple sclerosis should not be too surprising, in as much as that has been the concept for the past 20 or 30 years. To undertake a treatment using oxidative therapy should not otherwise be too unusual, since oxidative therapy is known to be anti-viral. 

The remarkable results in this particular case may be more than anti-viral in that the oxidative therapy itself may have had other attributes which led to the remarkable results that we re going to relate to you. In other words, there may have been other mechanisms, such as dramatic increases in interferon levels. There may be other factors with which we re not familiar at this time. 

May 23, and, with the patient s consent, we decided to begin a series of oxidative therapy treatments. 

A. "Yes we have. Nobody with this type of response, and I have a comment that perhaps should be made at this point This gentleman had just entered the wheelchair stage. When we saw him he had been in a wheelchair between one and two weeks. And I think that is very, very significant, because other people who have been in wheelchairs, say for two years, I really don t think you re going to get any kind of results anywhere like this. And, I think that before the wheelchair stage is where any good is going to be done, whether it is with oxidative therapy or any other kind of therapy."... 

Q. "And did they [other MS patients treated with oxidative therapy] generally improve, or was there just no change "... 

A. "Well, as you probably are aware, with oxidative therapy my experience has been that you usually don t come in with a patient who has MS only. They ll come in with MS, plus lung diseases, plus whatever. It s rare to find a person with just one illness. When they start responding in other directions, they usually are very exuberant about their response. I would say that we had varying degrees of success, none of which matched this particular case."... 

With the establishment of our African AIDS clinic, we are embarking on a new era in medicine. The despondent cry that nothing works is no longer true. The advent of bio-oxidative therapy, supplemented with photoluminescent therapy, means we now have weapons that will enable us to wage an effective holding action against the dreaded viral disease. 

E. L. Dobyns, D. N. Cornfield, N. G. Anas, et al Multicenter randomized control trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxic respiratory failure. Journal of Pediatrics 134,406(1999). 

Gladwin MT, Schechter AN. Nitric oxide therapy in sickle cell disease. Semin Hematol 2001 38 333-342. 

Kendall MJ, Nuttall SL Anti-oxidant therapy for the treatment of coronary artery disease. Expert Opin... 

Inhaled Nitric Oxide Therapy of Pulmonary Hypertension and Respiratory Failure in Premature and Term Neonates... 

Abman, S. H., Kinsella, J. P., Schaffer, M. S., and Wilkening, R. B. (1993). Inhaled nitric oxide therapy in a premature newborn with severe respiratory distress and pulmonary hypertension. Pediatrics 92, 606-609. 

Five of the 11 patients did not respond to inhaled nitric oxide therapy, with either a decrease in proximal pulmonary artery pressure or an increase in systemic oxygen saturation. Each of these neonates had a predisposition toward elevation of pulmonary vascular resistance postoperatively. Two of these five patients had severe pulmonary venous hypertension requiring... 

The exact method of delivery and monitoring of inhaled nitric oxide therapy varies with the clinical indication and duration of treatment. " A number of descriptions have appeared, including the Douglas bag, the titration of nitric oxide continuously into the inspiratory limb of the ventilator circuit, and the use of a ventilator nebulizer to deliver nitric oxide during inspiration only or double-blender techniques adaptable to a variety of circumstances. We reviewed our initial experience with delivery and monitoring techniques in a variety of clinical settings in 123 patients and subsequently adapted a system to simplify the delivery in continuous-flow circuits suitable for paralyzed infants, as many others have done before us. ... 

Myeloperoxidase is only one of the peroxidases in mammalian tissues utilizing hydrogen peroxide as the cofactor. The peroxidase content in cells from rat mammary tumours induced by 7,12-dimethylbenz(a)anthracene was much higher in tumours compared to normal tissue [70]. H2O2 production rates by human tumour cells, initially around 10 pmol dm s if the cell volume is nominally 1 pL, were reported to be comparable (over a 4 h period) to the levels produced by stimulated neutrophils in the respiratory burst [71]. Since peroxidases are capable of catalysing the oxidation of many potential drugs [72], this oxidative activity is the basis for a new approach to the oxidation therapy of cancer [73], as discussed below. 

L.K. Folkes, L.P. Candeias and P. Wardman, Toward targeted oxidation therapy of cancer peroxidase-catalysed cytotoxicity of indole-3-acetic acids, Int. J. Radiat. Oncol. Biol. Phys., 42 (1998) 917. 

O. Ben-Yoseph and B.D. Ross, Oxidation therapy the use of a reactive oxygen speciesgenerating enzyme system for tumour treatment, Br. J. Cancer, 70 (1994) 1131. 

Despite the numerous well-known complications of naturopathy and antioxidant therapy (antioxidants could blunt the effect of standard therapies, particularly alkylating, platinum, and tumor antibiotic agents, which are oxidative in nature), the biomedical research community has witnessed a remarkable optimism in the attitude of many conventional practitioners toward naturopathy and antioxidant therapy in recent years. Although this may appear as a theoretical concern, a plethora of pubhshed papers shows that this proposed interaction of anti- and pro-oxidant therapies has tremendous imphcations, and it is time to put this controversy in the proper perspective. Approaches to cancer therapy have been remarkably consistent for the last several decades. Smgeiy, radiation, and chemotherapy alone—or their reasonable... 

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