Organizing pneumonia

Lung Bronchiolitis obliterans diagnosed with lung biopsy Bronchiolitis obliterans diagnosed with pulmonary function tests and radiology0 Bronchiolitis obliterans organizing pneumonia... 

A limited form of Wegener s granulomatosis with a bronchiolitis obliterans organizing pneumonia-hke variant has been reported in a 19-year-old man, a non-smoker, with ulcerative colitis, 6 months after the introduction of mesalazine 2.25 g tds orally (43). He recovered after mesalazine withdrawal and treatment with glucocorticoids. 

Valle JM, Alvarez D, Antunez J, Valdes L. Bronchiohtis obhterans organizing pneumonia secondary to amiodarone a rare aetiology. Eur Respir J 1995 8(3) 470-1. 

Gold-induced lung toxicity is an infrequent adverse effect in patients with rheumatoid arthritis and psoriatic arthritis. There are three types interstitial pneumonitis, bronchiolitis obliterans with organizing pneumonia, and bronchiolitis obliterans the first is the most frequent. There have been two reports of gold-induced lung toxicity in psoriatic arthritis (16). 

Interferon alfa was also suspected to be involved in one case of biopsy-proven bronchiolitis obliterans-organizing pneumonia (41). Clinical symptoms of pneumonitis appeared 3-12 weeks after the onset of interferon alfa therapy, and after withdrawal of treatment they usually completely resolved, either spontaneously or after a short course of glucocorticoid treatment. Immune-mediated pulmonary toxicity involving the activation of T cells was considered as a likely mechanism. The uncommon features of bronchiolitis obliterans-organizing pneumonia have been reported in three other patients who received interferon alfa together with ribavirin or cytosine arabino-side (42,43). 

Ogata K, Koga T, Yagawa K. Interferon-related bronchiolitis obliterans organizing pneumonia. Chest 1994 106(2) 612-13. 

Patel M, Ezzat W, Pauw KL, Lowsky R. Bronchiolitis obliterans organizing pneumonia in a patient with chronic myelogenous leukemia developing after initiation of interferon and cytosine arabinoside. Eur J Haematol 2001 67 (5-6) 318-21. 

Bronchiolitis obliterans with organizing pneumonia has been reported in a patient taking interferon beta (13). 

A 49-year-old man had a progressive unproductive cough and right hemithoracic pain after 3 months of interferon beta-la 30 micrograms/week for multiple sclerosis. A CT scan showed a right basal pulmonary infiltrate and transbronchial biopsies showed features consistent with bronchiolitis obliterans with organizing pneumonia. The lesions resolved fully on interferon beta-la withdrawal and prednisone treatment. 

Acute lung reactions to nitrofurantoin are extremely rare in children (12). Lung tissue findings in acute reactions have shown minor vasculitis, granulomatous vasculitis (hypersensitivity angiitis), proliferation of endothelial cells, and empty alveoli (13). Rapidly progressing bronchiolitis obliterans with organizing pneumonia (BOOP) has been reported (14). 

Cohen AJ, King TE Jr, Downey GP. Rapidly progressive bronchiolitis obliterans with organizing pneumonia. Am J Respir Crit Care Med 1994 149(6) 1670-5. 

Bronchiohtis obliterans with organizing pneumonia has been attributed to sirolimus in two renal transplant patients (6). Both improved rapidly after sirohmus withdrawal or dosage reduction. 

Mahalati K, Murphy DM, West ML. Bronchiohtis obhter-ans and organizing pneumonia in renal transplant recipients. Transplantation 2000 69 1531-2. 

Bronchiolitis obliterans organizing pneumonia has been attributed to ticlopidine (1). 

Alonso-Martinez JL, Elejalde-Guerra JI, Larrinaga-Linero D. Bronchiolitis obliterans-organizing pneumonia caused by ticlopidine. Ann Intern Med 1998 129(l) 71-2. 

Late pulmonary complications cover a wide spectrum of disorders and include both obstructive and restrictive lung diseases. Included in these disorders are bronchiolitis obliterans with or without organizing pneumonia, diffuse alveolar damage, and lymphocytic interstitial pneumonia. 9,80 xjjgj- py consists of steroids, which are... 

Furthermore, a large-scale of intraabdominal or extraabdominal disorders can cause acute abdominal pain. Intraabdominal causes may have a genitourinary (urinary tract infection, ovarian torsion) or biliopancreatic origin (colecistitis, pancreatitis, etc.). Extraabdominal causes include abdominal pain referred from non-abdominal organs (pneumonia, discitis) and abdominal pain related to a systemic disease, such as diabetic acidosis, hypothyroidism, lead metals poisoning, sickle cell anemia, and porphyria. Fortunately, these different causes... 

Milne DS, Gascoigne AD, Ashcroft T, Sviland L, Malcolm AJ, Cotris PA. Organizing pneumonia following pulmonary transplantation and the development of obliterative bronchiolitis. Transplantation 1994 57 1757-1762. 

A 33-year-old man who had taken sertraline 50 mg/day and risperidone 2 mg/day for 3 years developed acute respiratory failure. A lung biopsy confirmed pulmonary fibrosis with eosinophilic and organizing pneumonia. He recovered on withdrawal of both agents and glucocorticoid therapy. 

Respiratory A 49-year-old man developed organizing pneumonia, with dyspnea, cough, weight loss, night sweats, and general malaise, after using oral fumaric add esters for psoriasis for 6 months [16 ]. 

Schindler K, Schima W, Kaliman JF. Cryptogenic organizing pneumonia due to amiodar-one long-term follow-up after corticosteroid treatment. Wien Klin Wochenschr 2010 122 (15-16) 511. ... 

Bitzan M, Ouahed JD, Carpineta L, Bernard C, Bell LE. Cryptogenic organizing pneumonia after rituximab therapy for presumed post-kidney transplant lym-phoproliferative disease. Pediatr Nephrol 2010 25 1163-7. 

Interstitial Lung Diseases That Have No Known Cause 338 Idiopathic Interstitial Pneumonias 33S Idiopathic Pulmonary Fibrosis 339 Nonspecific Interstitial Pneumonia 339 Cryptogenic Organizing Pneumonia 339... 

The term idiopathic interstitial pneumonias refers to a group of seven entities with distinct histologic patterns idiopathic pulmonary fibrosis (IFF), characterized by the pattern of usual interstitial pneumonia (UIP) nonspecific interstitial pneumonia (NSIP) cryptogenic organizing pneumonia (COP) respiratory bron-chiohtis-associated interstitial lung disease (RB-ILD) desquamative interstitial pneumonia (DIP) lymphoid interstitial pneumonia (LIP) and acute interstitial pneumonia (AIP). 

COP was formerly referred to as bronchiolitis obliterans organizing pneumonia (BOOP) and is characterized by the histologic pattern of organizing pneumonia (OP). There is no gender predilection. Patients usually present between 50 and 60 years of age, and typically report... 

Fig. 26.25. A 63-year-old man with organizing pneumonia (OP). The patient was receiving amiodarone for cardiac arrhythmia. Coronal CT image shows bilateral areas of ground-glass opacities in subpleural distribution (arrowheads)...

Akira M, Yamamoto S et al. (1998) Bronchiolitis obliterans organizing pneumonia manifesting as multiple large nodules or masses. AJR Am J Roentgenol 170 291 -295... 

Lee KS, Kullnig P etal. (1994) Cryptogenic organizing pneumonia CT findings in 43 patients. AJR Am J Roentgenol 162 543-546... 

Oikonomou A, Hansell DM (2002) Organizing pneumonia the many morphological faces. Eur Radiol 12 1486-1496... 

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