Bronchiolitis obliterans organizing pneumonia BOOP

COP was formerly referred to as bronchiolitis obliterans organizing pneumonia (BOOP) and is characterized by the histologic pattern of organizing pneumonia (OP). There is no gender predilection. Patients usually present between 50 and 60 years of age, and typically report... 

Bouchardy LM, Kuhhnan JE, Ball WC Jr., et al. CT findings in bronchiolitis obliterans organizing pneumonia (BOOP) with radiographic, clinical, and histologic correlation. J Comput Assist Tomogr 1993 17(3) 352 357. 

A number of bronchiolar alterations have been described including proliferative bronchiolitis obhterans in FLD (82), peribronchiolar inflammation/ fibrosis with smooth muscle hypertrophy, and extrinsic narrowing of the small airways in pigeon breeder s disease (83), and less frequently, bronchiolitis obliterans organizing pneumonia (BOOP)-like lesions (84). 

Costahel U, Teschler H, Guzman J. Bronchiolitis obliterans organizing pneumonia (BOOP) the c3hological and immunocytological profile of bronchoalveolar lavage. Eur Respir J 1992 5 791-797. 

Uner AH, Rozum-Slota B, Katzenstein AL. Bronchiolitis obliterans-organizing pneumonia (BOOP)-like variant of Wegener s granulomatosis. A clinicopathologic study of 16 cases. Am J Surg Pathol 1996 20 794-801. 

Figure 6 (See color insert.) Lung pathology in BOOP showing the presence of intraluminal granulation tissue in bronchioli, alveolar ducts, and alveoli. There is also interstitial infiltration with mononuclear cells and foamy macrophages (hematoxylin and eosin stain). Abbreviation BOOP, bronchiolitis obliterans organizing pneumonia. Source Adapted from Ref. 5.

Histologically diffuse alveolar damage (DAD) or BOOP-like reactions (BOOP is bronchiolitis obliterans organizing pneumonia) are described. Any change in the chest X-ray beginning after day 5 should be assumed to be due to some other cause such as infection or rejection. 

Acute lung reactions to nitrofurantoin are extremely rare in children (12). Lung tissue findings in acute reactions have shown minor vasculitis, granulomatous vasculitis (hypersensitivity angiitis), proliferation of endothelial cells, and empty alveoli (13). Rapidly progressing bronchiolitis obliterans with organizing pneumonia (BOOP) has been reported (14). 

Bronchiolitis obliterans with organizing pneumonia (BOOP) is now called cryptogenic organizing pneumonia (COP) when the cause is idiopathic (50). When secondary to a CTD, such as RA or SSc, variable terminology is used. 

The wording used by Epler gave rise to semantic confusion between bronchiolitis obliterans (usually associated with airflow obstmction) and bronchiolitis obliterans with organizing pneumonia (BOOP), which are clinically and histologically distinct entities. The term BOOP has thus been replaced by the more accurate term of organizing pneumonia (23), since bronchiolitis obliterans... 

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