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Organic cation transport basolateral transporter

Sweet DH, Miller DS, Pritchard JB. Basolateral localization of organic cation transporter 2 in intact renal proximal tubules. Am J Physiol Renal Physiol 2000 279(5) F826—F834. [Pg.204]

Y. Urakami, N. Kimura, M. Okuda, and K. Inui. Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney. Pharm Res 21 976-981... [Pg.574]

The family of organic cation transporters is represented at the apical membrane of intestinal cells by OCTN2, whereas the basolateral membrane is equipped with... [Pg.457]

Many studies have been performed to characterize the requirements for a substrate to be transported by the "organic cation transport mechanism" [97-100]. As for organic anions, the molecular structure of substrates is rather unspecific. Hydrophobicity and basicity are the general characteristics of substrates, but their ionization is not a prerequisite for interacting with the basolateral carrier [65]. Similar properties were found in brush border membrane [97-100]. Although the ratio of basolateral to apical membrane affinities may vary with substrates and animal species [97]. [Pg.57]

Molecular Identification of putative basolateral organic cation transporter belonging to the OCT family... [Pg.57]

Many other compounds interact at the basolateral membrane with the PAH and the organic cation transport systems as was demonstrated by the systematic studies by Ullrich et al. [37]. [Pg.63]

Sugawara-Yokoo M, Urakami Y, Koyama H, Fujikura K, Masuda S, Saito H, NaruseT, Inui K,Takata K. Differential localization of organic cation transporters rOCTI and rOCT2in the basolateral membrane of rat kidney proximal tubules. Histochem Cell Biol 2000 114 175-180. [Pg.68]

OCTNl, OCTN2. Two organic cation transporters, OCTNl and OCTN2, were identified in the kidney and other organs of rats, mice, rabbits and human, by their homology to the basolateral transporter OCT [53, 54,... [Pg.36]

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See also in sourсe #XX -- [ Pg.57 ]

See also in sourсe #XX -- [ Pg.35 ]



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