Organic cation transport multidrug transporter

Chen, Y., Zhang, S., Sorani, M. and Giacomini, K.M. (2007) Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. The Journal of Pharmacology and Experimental Therapeutics, 322, 695-700. [Pg.319]

Organic Cation Transporter Family Organic Cation Transporters (OCT, SLC22A) and Multidrug and Toxic Compound Extrusion Transporters (MATE)... [Pg.180]

ABC, ATP-binding cassette transporter superfamily ASBT, apical sodium-dependent bile salt transporter BCRP, breast cancer resistance protein BSEP, bile salt export pump MDRl, multidrug resistance MRR multidrug resistance-related protein NTCP, sodium taurocholate cotransporting polypeptide OAT, organic anion transporter OCT, organic cation transporter SLC, solute-linked carrier transporter family SLCO, solute-linked carrier organic anion transporter family. [Pg.88]

Carrier-mediated membrane transport proteins on the RPE selectively transport nutrients, metabolites, and xenobiotics between the choriocapillaris and the cells of the distal retina, and include amino acid [33 35], peptide [36], dicarboxylate, glucose [37], monocarboxylic acid [38,39], nucleoside[40], and organic anion and organic cation [41] transporters. Membrane barriers such as the efflux pumps, including multidrug resistance protein (P-gp), and multidrug resistance-associated protein (MRP) pumps have also been identified on the RPE. Exploitation of these transport systems may be the key to circumventing the outer BRB. [Pg.486]

Ohta, K.Y., Inoue, K., Hayashi, Y. and Yuasa, H. (2006) Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+... [Pg.318]