Organic cation transporter family

Okuda et al. (66) isolated rat Oct2 from kidney, which was subsequently followed by the identification of human OCT2 (60). The OCT2 mRNA has been detected in kidney and brain (60). The OCT2 has been localized 

The OCT3 was cloned from a human kidney carcinoma cell line (70). The OCT3 mRNA can be detected in multiple tissues including intestine, kidney, and brain with the highest expression noted in placenta (71). This transporter mediates the uptake of neurotransmitters such as epinephrine, norepinephrine, and MPP+ (70). To date, several synonymous variants have been reported for OCT3 (72,73) (www.vanderbilt.edu/kimlab). 

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Wu, X., et al. cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem. Biophys. Res. Commun. 1998, 246, 589-595. 

Novel Organic Cation Transporter Family (OCTN) 1193... 

Organic Cation Transporter Family Organic Cation Transporters (OCT, SLC22A) and Multidrug and Toxic Compound Extrusion Transporters (MATE)... 

Cell lines, such as the Caco-2 and MDCK cells [27, 35, 47, 49, 57, 67, 128-133], have been used frequently to study different transporters in the GI tract. These cell lines have been evaluated for transport both in absorptive and secretory direction and in addition also been transfected with specified transporter systems of interests to yield new clones [23, 31, 72, 79, 80, 134] or co-cultures [135], Some of the uptake transporters belonging to the organic cation transporter (OCT) family have also been identified in cell lines such as the pig kidney cell line LLC-PK1, and MDCK [67, 136]. In fact, its presence in Caco-2 cells needs to be further elucidated as reports have shown both the absence and presence of transporters from this family of transporters [136-138],... 

The family of organic cation transporters is represented at the apical membrane of intestinal cells by OCTN2, whereas the basolateral membrane is equipped with... 

One of the many families included in the MFS is the SLC (solute carrier) superfamiiy. The SLC superfamiiy represents approximately 300 genes in the human genome that encode for either facilitated transporters or secondary active symporters or antiporters. Members of the SLC superfamiiy transport various ionic and nonionic endogenous compounds and xenobiotics. The SLC22 family includes anion and cation transporters (Organic Anion Transporters, OATs Organic Cation Transporters, OCTs). 

Table 6. Organic cation transporter (OCT) families (from [34], with permission). ...

Molecular Identification of putative basolateral organic cation transporter belonging to the OCT family... 

Chen, Y., Zhang, S., Sorani, M. and Giacomini, K.M. (2007) Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. The Journal of Pharmacology and Experimental Therapeutics, 322, 695-700. 

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