Ranitidine organic cation transport

PROCAINAMIDE H2 RECEPTOR BLOCKERS Cimetidine may t plasma concentrations of procainamide Cimetidine is a potent inhibitor of organic cation transport in the kidney, and elimination of procainamide is impaired. Cimetidine also inhibits CYP2D6-mediated metabolism of procainamide. Ranitidine is a much weaker CYP2D6 inhibitor Monitor PR and BP at least weekly until stable. Warn patients to report symptoms of hypotension (lightheadedness, dizziness on standing, etc.). Consider alternative acid-suppression therapy... 

The nephrotoxicity of dsplatin is reduced in humans [132], mice [133] and dogs [134] by co-admin-istration of probenecid, suggesting that cisplatin is transported by the PAH transport system. It has been proposed that platinum, hke other nephrotoxic metal ions such as mercury and potassium dichromate, are taken up by tubular cells as sulphydryl conjugate through a probenecid-sensitive pathway [133]. However, cisplatin might also be transported by the organic cation transport system, since quinidine, cimetidine and ranitidine inhibited its net secretion flux in the dog kidney [134]. 

Lamivudine is cleared predominantly from the body by the kidneys using the organic cationic transport system however, cimetidine and ranitidine, which partly use this mechanism, do not interact with lamivudine. ... 

---