Organic cation transport glycoprotein

The existence of a carrier-mediated transport in nasal mucosa was first suggested by Kimura et al. [34], P-glycoprotein, organic cation transporter, dopamine transporter, and amino acid transporters have all been identified in the nasal mucosa, especially in the olfactory mucosa [31, 32, 35, 36], These transporters determine the polarized absorption and excretion of their substrates including amino acids, amines, and cations. 

C. D., Characterization of MMP+ secretion across human intestinal Caco-2 cell monolayers role of P-glycoprotein and a novel Na+-dependent organic cation transport... 

Nelson, J. A., Dutt, A., Allen, L. H., Weight, D. A., Functional expression of renal organic cation transporter and P-glycoprotein in Xenopus laevis oocytes, Cancer Chemother. Pharmacol. 1995, 37, 187-189. 

Saitoh H, Aungst BJ (1995) Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine. Pharm Res 12 1304-1310... 

Methods of traversing the basolateral membrane include uptake systems for organic cations and anions via fadhtated diffusion and/or active transport [1]. Organic anions and cations cross the basolateral membrane via ATP-driven or secondary active processes (H -antiport) [2]. Basolateral uptake processes include the gamma-glutamyl transport system [3] and those for glycoproteins [4]. Certain proteins (insulin, epidermal growth factor (EGF)) are transcytosed across the tubular cells from the blood to the tubular lumen via receptor-mediated uptake [5]. 

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