Excretion organic cation transporters

Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Octl [Slc22al]) gene, Mol. Cell. Biol. 2001, 23, 5471-5477. 

The existence of a carrier-mediated transport in nasal mucosa was first suggested by Kimura et al. [34], P-glycoprotein, organic cation transporter, dopamine transporter, and amino acid transporters have all been identified in the nasal mucosa, especially in the olfactory mucosa [31, 32, 35, 36], These transporters determine the polarized absorption and excretion of their substrates including amino acids, amines, and cations. 

The OAT family of transporters can be inhibited by probenecid. If a substrate of this family of transporters, such as penicillin, is administered concomitantly with probenecid, the dmg can have decreased renal secretion, with a resulting increase in the plasma penicillin concentration. Cimetidine is an inhibitor of members of the OAT, organic cation transporter (OCT) and OATP families of transporters This inhibition has been shown to result in a decrease in the renal excretion of substrates such as procainamide and levofloxacin, resulting in increased plasma concentrations of these dmgs. 

Paliperidone There was no clinically significant pharmacokinetic interaction of co-tri-moxazole, an inhibitor of organic cation transport, and paliperidone, which is an organic cation that is mainly eliminated by renal excretion paliperidone did not affect steady-state plasma concentrations of trimethoprim [195 ]. 

M. Otsuka, T. Matsumoto, R. Morimoto, S. Arioka, H. Omote, and Y. Moriyama. A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 102 17923-17928 (2005). 

Roch-Ramel F, Besseghir K, Murer H. Renal excretion and tubular transport of organic anions and cations. In Handbook of physiology, section 8 renal physiology. Windhager EE (editor). Oxford University Press, NewYork/Oxford 1992 p. 2189-2262. Guggino SE, Aronson PS. Paradoxical effects of py razinoate and nicotinate on urate transport in dog renal microvillus membranes. J Clin Invest 1985 76 543-547. 

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