Human organic cation transporter

Bednarczyk D, Ekins S, Wikel JH and Wright SH. Influence of molecular structure on substrate binding to the human organic cation transporter, hOCTl. Mol Pharmacol 2003 63 489-98. 

G. Ciarimboli, T. Ludwig, D. Lang, H. Pavenstadt, H. Koepsell, H. J. Piechota, J. Haier, U. Jaehde, J. Zisowsky, and E. Schlatter. Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol 167 1477-1484... 

Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto Y, Cha SH, Sekine T, Endou H. Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther 2002 300 918-924. 

Dresser MJ, Gray AT, Giacomini KM. Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1). J Pharmacol Exp Ther 2000 292 1146-1152. 

Schinkel AH, Jonker JW. Polymorphisms affecting function of the human organic cation transporter hOCTl (SLC22A1) What are the consequences Pharmacogenetics 2002 12 589-90. 

Zhang L,GorsetW, Washington CB, BlaschkeTF, Kroetz DE, Giacomini KM. Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metab Dispos 2000 28 329-334. 

Ahlin, G., Karlsson, J.E., Pedersen, J., Gustavsson, L., Larsson, R., Matsson, P., Norinder, U., Bergstrom, C.A.S. and Artursson P. (2008) Structural requirements for drug inhibition of the human organic cation transport protein OCT1 (SLC22A1). Journal of Medical Chemisty, (submitted). 

Chen, Y., Zhang, S., Sorani, M. and Giacomini, K.M. (2007) Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. The Journal of Pharmacology and Experimental Therapeutics, 322, 695-700. 

Saborowski, M., Kullak-Ublick, G. A., and Eloranta, J. J. (2006) The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha. J. Pharmacol. Exp. Ther. 317, 778-785. 

Zolk O, Solbach TF, Konig J, and Fromm MF (2009) Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 ( SLC22A2 ). Naunyn-Schmied Arch Pharmacol 379 337-348. 

Drug Metabol. Disposition, 28, 329 (2000). Interactions of HIV Protease Inhibitors with a Human Organic Cation Transporter in a Mammalian Expression System. 

Influence of Molecular Structure of Substrate Binding to the Human Organic Cation Transporter, hOCTl. 

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