Optimization approach

Papoulias, S. A., and Grossmann, I. E., A Structural Optimization Approach in Process Synthesis II. Heat Recovery Networks, Computers Chem. Eng., 7 707, 1983. 

A novel optimization approach based on the Newton-Kantorovich iterative scheme applied to the Riccati equation describing the reflection from the inhomogeneous half-space was proposed recently [7]. The method works well with complicated highly contrasted dielectric profiles and retains stability with respect to the noise in the input data. However, this algorithm like others needs the measurement data to be given in a broad frequency band. In this work, the method is improved to be valid for the input data obtained in an essentially restricted frequency band, i.e. when both low and high frequency data are not available. This... 

C.D. Maranas, IP. Androulakis and C.A. Floudas, A deterministic global optimization approach for the protein folding problem, pp. 133-150 in Global minimization of nonconvex energy functions molecular conformation and protein folding (P. M. Pardalos et al., eds.), Amer. Math. Soc., Providence, RI, 1996. 

Research looking into tolerance allocation in assembly stacks is by no means new. A current theme is towards an optimization approach using complex routines and/ or cost models (Lin et al., 1997 Jeang, 1995). Advanced methods are also available, such as Monte Carlo Simulation and Method of Moment. ) (Chase and Parkinson, 1991 Wu et al., 1988). The approach presented here is based on empirical process capability measures using simple tolerance models, cost analogies and optimization... 

El-Halwagi, M. M. (1995). Introduction to numerical optimization approaches to pollution prevention. In Waste Minimization Through Process Design, (A. P. Rossiter, ed.) pp. 199-208, McGraw Hill, New York. 

Saraiva, P.M. and Stephanopoulos, G., 1992b. An exploratory data analysis robust optimization approach to continuous process improvement. Working Paper, Dept. Chem. Eng. MIT, Cambridge MA. 

How many organizations do what we could really call direct rational solution of the composite structure design problem — very, very few. Perhaps only in some very restricted design areas do people feel that they can use a mathematically oriented optimization approach. That situation is unfortunate, but changing. 

Figure 3.4. Optimization approaches. The classical approach fixes all factors except one, which is systematically varied (rows of points in left panel) the real optimum (x) might never be found this way. The brute-force approach would prescribe experiments at all grid points (dotted lines), and then further ones on a finer grid centered on 80/1 2, for example.

Assays, screening sequence, subset and cutoff criteria, iead optimization approach, resourcing... 

OASIS (optimized approach based on structural indices set) has been developed by Mekenyan and co-workers [87]. Given the activities or toxicities of a set of compounds, it generates large numbers of structural indices for each and develops QSAR correlations. The approach has been used to model the acute toxicity of industrial chemicals [88]. It is claimed [89] that the method can be of use in elucidating mechanisms of action. 

Fig. 1.13 Adenosine kinase inhibitor designed using fragment optimization approach.

Inducing and maintaining remission of IBD prior to conception is the optimal approach in women planning to become pregnant. Active IBD may result in prematurity and low birth weight. Thus, pregnant women with IBD should be monitored closely, particularly during the third trimester.44... 

Remediation optimization uses defined approaches to improve the effectiveness and efficiency with which an environmental remedy reaches its stated goals. Optimization approaches might include third-party site-wide optimization evaluations conducted by expert teams, the use of mathematical tools to determine optimal operating parameters or monitoring networks, or the consideration of emerging technologies. Since 1999, U.S. EPA has promoted remediation optimization in the following manner ... 

It has worked on outreach efforts with many State and Federal partners to disseminate information on new optimization approaches for streamlining long-term remedial action. 

Zhu XX and Asante NDK (1999) Diagnosis and Optimization Approach for Heat Exchanger Network Retrofit, AIChE J, 45 1488. 

Majozi, T., Gouws, J., 2009. A mathematical optimization approach for wastewater minimization in multiple contaminant batch plant. Comput. Chem. Eng. doi 10.1016/j.compchemeng. 2009.06.008... 

Fig.2 Melting temperatures of polymers (faTm/Ec) with variable chain lengths. The solid line is calculated from Eq. 10, the dashed line is calculated from Flory-Vrij analysis (Eq. 11), and the circles are the simulation results in the optimized approach. In simulations, the occupation density is 0.9375, and the linear size of the cubic box is set to 32 for short chains and 64 for long chains (Hu and Frenkel, unpublished results)...

Fig. 3 Liquid-liquid demixing curves (dashed lines denoted by T ) and liquid-solid transition curves (solid lines denoted by Tm) of polymer solutions with variable energy parameter sets [denoted by T(EV/EC, B/Ec)]. The solution system is made of 32-mers in a 32-sized cubic box. a Theoretical curves b simulation results in the optimized approach [14]...

In a study on another manganese enzyme, glutathione transferase, the Hoffmann group has proposed Q-band dispersion EPR at the unusually low temperature of 2 K as the optimal approach to collect data from Mn11 centers with D hv (Smoukov et al. 2002). This proposal would be practically limited by the fact that Q-band spectrometers running at 2 K can be counted on the fingers of one finger however, dispersion spectra are readily obtained in Q-band also at helium-flow temperatures (i.e., T>4.2K). 

Subash Balakrishna and Lorenz T. Biegler, Chemical Reactor Network Targeting and Integration An Optimization Approach... 

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