Granuloma inguinale

Granuloma inguinale (donovanosis) - 100 mg twice daily for at least 3 weeks. 

For granuloma inguinale the first choice of treatment is cotrimoxazole 2 x 960 mg orally for two weeks. Alternatives are doxycycline 2 x 100 mg orally for 2 weeks or oral azithromycin 1 g weekly for 4 doses, or 1 x 500 mg daily for 7 days. 

The tetracyclines are still the drugs of choice for treatment of cholera, diseases caused by Rickettsia and Coxiella, granuloma inguinale, relapsing fever, the chlamydial diseases (trachoma, lymphogranuloma... 

Respiratory, skin, and soft-tissue infections UTIs pelvic inflammatory disease (PID) brucellosis trachoma Rocky Mountain spotted fever typhus Q fever lickettsia severe acne (Adoxa) smallpox psittacosis ornithosis granuloma inguinale lymphogranuloma venereum intestinal amebiasis (adjunctive treatment) prevention of rheumatic fever ... 

Granuloma inguinale -use of tetracyclines against [ANTIBIOTICS - TETRACYCLINES] (Vol3)... 

The spectrum of sexually transmitted diseases (STDs) includes the classic venereal diseases—gonorrhea, syphilis, chancroid, lymphogranuloma venereum, and granuloma inguinale—as well as a variety of other pathogens known to he spread hy sexual contact (Table 46-1). Common clinical syndromes associated with STDs are listed in Table 46-2. The most current information on epidemiology, diagnosis, and treatment of STDs provided by the Centers for Disease Control and Prevention (CDC) can be found at http //www.cdc.gov. 

This chapter is a review of the antimicrobial susceptibilities of the causative organisms and the treatment of the sexually transmitted infections most prevalent in North America and Western Europe, gonorrhea, nongonococcal urethritis, genital herpes virus infections, and trichomoniasis. Because of their relative rarity or because no important advances in therapy have been made in the past decade, syphilis, lymphogranuloma venereum, chancroid, and granuloma inguinale are not considered. 

Granuloma inguinale—Granuloma lesions affecting the genital area. 

Tetracyclines are effective in the treatment of Rocky Mountain spotted fever, murine typhus, recrudescent epidemic typhus, scrub typhus, Q fever, lymphogranuloma venereum, psittacosis, tularemia, brucellosis, gonorrhea, certain urinary tract infections, granuloma inguinale, chancroid, syphilis, and disease due to Bacteroides and Clostridium. 

The drug is the durg of choice in the treatment of ehloera, relapsing fever, granuloma inguinale and infeetions produced by rickettsia, Borrelia, Mycobacterium fortuitum and marinum, and Chlamydia psittaci and trachomatis (except pneumonia and inclusion conjunctivitis). 

Donovan body A large monon-uclear cell found in scrapings of lesions that confirms the presence of granuloma inguinale. 

Granuloma inguinale A sexually transmitted disease caused by Calymmatobacterium Granulomatis. 

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