In chlamydial infections

Type of Infection Uncomplicated infections of the cervix, urethra, and rectum in adultsc,d Recommended Regimens0 Ceftriaxone 125 mg IM once/ or cefixime 400 mg po once/5 or ciprofloxacin 500 mg po once/ or ofloxacin 400 mg po once/ or levofloxacin 250 mg po once plus A treatment regimen for presumptive C. trachomatis coinfection if chlamydial infection has not been ruled out (see Table 121 -8 in Pharmacotherapy A Pathophysiologic Approach, seventh edition)... 

A treatment regimen for presumptive C trachomatis coinfection if chlamydial infection has not been ruled out (see Table 121-8 in Pharmacotherapy A Pathophysiologic Approach, seventh edition)... 

In comparison with gonorrhea, chlamydial genital infections are more frequently asymptomatic, and when present, symptoms tend to be less noticeable. Table 46-7 summarizes the usual clinical presentation of chlamydial infections. 

Recommended regimens for treatment of chlamydial infections are given in Table 46-8. Single-dose azithromycin and 7-day doxycycline are the... 

Efficacy In other conditions The clinical efficacy in the treatment of stromal keratitis and uveitis caused by herpes simplex or ophthalmic infections caused by vaccinia virus and adenovirus, or in the prophylaxis of herpes simplex virus keratoconjunctivitis and epithelial keratitis has not been established by well-controlled clinical trials. Not effective against bacterial, fungal, or chlamydial infections of the cornea or trophic lesions. 

Tetracyclines remain the agents of choice in rickettsial infections, and are also used in chlamydial, vibrio, mycoplasmal and spirochaetal infections, brucellosis and the management of chronic bronchitis and acne. They are used in combination with other agents in the treatment of malaria and amoe-biasis, and doxycycline is used for prophylaxis of malaria. 

Although erythromycin is a well-established antibiotic, there are relatively few primary indications for its use. These indications include the treatment of Mycoplasma pneumoniae infections, eradication of Corynebacterium diphtheriae from pharyngeal carriers, the early preparox-ysmal stage of pertussis, chlamydial infections, and more recently, the treatment of Legionnaires disease, Campylobacter enteritis, and chlamydial conjunctivitis, and the prevention of secondary pneumonia in neonates. 

Inflammatory acne vulgaris, Lyme disease, mycoplasmal disease, Legionella infections. Rocky Mountain spotted fever, chlamydial infections in patients with gonorrhea PO... 

Chloramphenicol is used topically in the treatment of eye infections because of its broad spectrum and its penetration of ocular tissues and the aqueous humor. It is ineffective for chlamydial infections. 

In the latter instance, however, the clinician should be aware that a significant number of patients with gonococcal urethritis have uninformative Gram stains for the organism and that a significant number of patients with gonococcal urethritis harbor concurrent chlamydial infection that is not demonstrated on the Gram-stained smear. 

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