Treatment during Pregnancy

Czeizel AE, Rockenbauer M, Olsen J, Sorensen HT A population-based case-control study of the safety of oral anti-tuberculosis drug treatment during pregnancy. Int J Tu-berc Lung Dis 2001 5 564-568. 

Korte, M., Stahlmann, S.R., Neubert, D. Induction of hepatic monooxygenases in female rats and offspring in correlation with TCDD concentrations after single treatment during pregnancy, Chemosphere, 20, 1193, 1990. 

Pregnancy may be adversely affected by poorly controlled hyperthyroidism, with an increased rate of fetal loss. The goal of treatment during pregnancy is to maintain euthyroidism, using the smallest doses of anti thyroid drugs possible. 

Reproductive toxicity data, particularly as relating to treatment during pregnancy, remain relevant throughout the life-time of a compound unless well-designed studies in humans become available either to confirm or negate the animal data. 

Koch, S., Titze, K., Zimmermann, R.B., Schroder, M., Lehmkuhl, U., and Rauh, H. (1999) Long-term neuropsychological consequences of maternal epilepsy and anticonvulsant treatment during pregnancy for school-age children and adolescents. Epilepsia 40 1237-1246. 

Schou M. Lithium treatment during pregnancy, delivery, and lactation an update. J Clin Psychiatry 1990 51 410-412. 

Goh KO. Radioiodine treatment during pregnancy chromosomal aberrations and cretinism associated with maternal iodine-131 treatment. J Am Med Womens Assoc 1981 36(8) 262-5. 

Mice treated with phenobarbital (40 mg/kg) on the last 6-7 days before birth showed decreased passive avoidance latencies in the test session at the age of 90 days (ref. 138). Delta-9-THC treatment during pregnancy caused a decreased rate of learning a passive avoidance response on postnatal day 21. However, on day 90 no difference in passive avoidance learning was found (ref. 156). 

Czeizel, A. E., Kazy, Z., and Vargha, P. (2003), A population-based case-control terato-logical study of vaginal econazole treatment during pregnancy, Eur. J. Obstet. Gynecol. Reprod. Biol., Ill, 135-140. 

Eros E, Czeizel AE, Rockenbauer M, Sorensen HT, Olsen J. A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatment during pregnancy. Eur J Obstet Gynecol Reprod Biol 2002 101(2) 147-54. 

Czeizel AE, Szegal BA, Joffe JM, Racz J. The effect of diazepam and promethazine treatment during pregnancy on the somatic development of human offspring. Neurotoxicol Teratol 1999 21(2) 157-67. 

For many patients this may mean continuing treatment during pregnancy... 

Nonetheless, continuous treatment during pregnancy may be necessary and has not been proven to be harmful to the fetus... 

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