NO , cytotoxic effects

High specific activity compound marked therapeutic efficacy by lung colony assay. Localization of 4- At-methylene blue in intracellular melanin. No cytotoxic effect with At ... 

Cherukuri et al. [15] SW CNT, purified Phagocytic cells of mice (J774.1) Catching -50% of nanotubes, no cytotoxic effect... 

A thorough investigation12 of the effects of the unsaturated ketonu-cleoside 61a on KB cells in culture confirmed the high cytotoxic potency of this compound. Moreover, it appeared that, at low doses, where no cytotoxic effect occurs, the ketonucleoside impaired DNA, RNA, and protein synthesis, and strongly inhibited cell multiplication. 

Using human keratinocytes (HaCaT cells) to determine the direct interaction of purified BC with cells in culture, good biocompatibility of BC with cells was shown, with no cytotoxicity effects. 

A report that hydroxytamoxifen can form quinone methides (QM) as a result of bio-oxidation [151] inspired an electrochemical study of some of the compounds discussed in the structure-activity relationship study ([128, 129], reviewed in [152]). In MeOH medium alone (these compounds are only sparingly soluble in water), the cyclic voltammograms (CV) of most of the compounds exhibited the expected reversible Fc/Fc+ redox couple, often followed by that of the phenolic moiety (where appropriate). However, when an organic base such as pyridine was added, two distinct types of electrochemical behaviour were observed. In the cases of the compounds which showed low or no cytotoxic effects in vitro, very little change in the CV was observed upon the addition of base. However, for the most... 

AI2O3 and Zr02 are considered to be nonbioactive ceramics and are frequently used as the articular heads of total arthroplasties such as total hip prostheses, total shoulder prostheses, and maxillar articular replacements. No unwanted biological effects could be observed in vivo, and no cytotoxic effects have been evidenced in vitro for both compounds except for some formation of granuloma around wear particles of these materials. Oonishi et al. (1997) have also shown small amounts of new bone formation between AI2O3 particles in an experimental rabbit femoral defect model. 

Sulfated derivatives of a polysaccharide prepared by chlorosulfonic acid treatment of a fucosamine-containing polysaccharide from a marine Pseudomonas sp. showed strong anti-HSV-1. This sulfated polysaccharide inhibited the CPE of HSV-1 at 0.72 0,g/mL. No cytotoxic effects on Vero cells were detected up to 1000 0,g/mL [216]. Another study indicated the inhibition of HIV-1 replication in MT-4 cells by a sulfated derivative of fucosamine-containing polysaccharide obtained from a marine Pseudomonas strain HA-318 and also showed no cytotoxicity [217]. 

The results of the determination of cytotoxicity of PSU and its composites (PSU/Ag) for human osteoblasts and human fibroblasts by the LDH test are compiled in Table 3. For the composites with the polysulfone matrix with the highest content of nano-silver, the cytotoxicity of non-diluted extracts did not exceed 3% after 24 h and 7% after 48 h of their incubation with osteoblasts. In the case of diluted extracts, the values did not exceed 5% and 8%, after 24 and 48 h, respectively. Pure PSU demonstrated no cytotoxic effect, which is verified by the literature data on its biocompatibility. In the case of fibroblasts, the LDH test, similarly to the MTT test, showed a higher cytotoxicity of the examined materials. 

Those of interest in the present context are short chain N -substituted adenosine analogues, namely, the allyl, -CH2 CH-CH2 isopropyl, -CH(CH3 >2 propargyl, -CH2 C=H and 2-(methylallyl), -CH2C(CH3)=CH2 [26]. All show cytotoxic effects in a number of in vitro and in vivo tumour cell systems. The authors state that an interesting finding was that these compounds had no cytotoxic effect on a leucocyte cell line in vitro which had originated from normal cells this observation was not pursued further by them. 

Marigold Tagetes minuta L.) and basil (O. basilicuni) (Lamiaceae) EO showed in vitro cytotoxic effects at concentrations of 25-200 pg/mL. Both EOs reduced the cell viability of HL-60 and NB4 (human leukemia cell line) cells. 82.33% of cell death of HL-60 cells was reached at a concentration of 200 pg/mL basil oil. The highest rate of cell death on NB4 cells (81.87%) was reached with marigold oil at a concentration of 200 pg/mL. Both EOs showed no cytotoxic effects in the in vivo tests (Mahmoud, 2013). 

CBO-Pll, a specific inhibitor of vascular endothelial growth factor and other angiogenic pathways, was efficiently incorporated in multifunctional anti-VC AM-1 and anti-ICAM-1 polyurethane-urea nanoparticles." These systems showed a significant and selective blockade of the proliferation only in inflamed endothelial cells and no cytotoxic effect was observed in healthy cells. Moreover, in vivo studies in CDl mice demonstrated that these nanoparticles reach the target site after intravenous administration. 

When DIPHOTERINE solution was compared to SLS (sodium lauryl sulfate) in a murine fibroblast MTT cytotoxicity assay, the estimated IC50 of SLS was 0.258 mg/mL whereas that of DIPHOTERINE solution was 5 mg/mL even after 24 h of incubation. Thus, DIPHOTERINE solution had no cytotoxic effects on murine fibroblasts [256]. 

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