Polyurethane-urea nanoparticles

Morral-Ruiz G, Melgar-Lesmes P, Solans C, Garcia-Celma MJ. Multifunctional polyurethane-urea nanoparticles to target and arrest inflamed vascular environment a potential tool for cancer therapy and diagnosis. J Control Release October 28,2013 171(2) 163-71. 

Cheong I, Kim J. Synthesis of core-shell polyurethane-urea nanoparticles containing 4,4 -methylenedi-p-phenyl diisocyanate and isophorone diisocyanate by self-assembled neutralization emulsification. Chem Commun 2004 21 2484-5. 

Multifunctional biotinylated and streptavidin-coated polyurethane-urea nanoparticles have also been engineered from OAV nano-emulsions." " In these studies, biotin or streptavidin reacts with diisocyanate at the droplet interface and are successfully attached to the nanoparticle polymeric matrices. These nanoparticles exhibit diameters around 110-140mn (biotin nanoparticles) and 70-74nm (streptavidin nanoparticles). In addition, streptavidin-coated polyurethane-urea nanoparticles were functionalized with biotin anti-VCAM-1 and anti-ICAM-1 antibodies for specific targeting. Both nanoparticulate systems showed no cytotoxicity in healthy endothelial cells and therefore good biocompatibility properties. Figure 7.1 shows a schema of the synthesis of different polyurethane nanoparticles obtained from 0/W nano-emulsions by interfacial polymerization and images obtained by transmission electron microscopy. 

Figure 7.1 Fonnation of different polyurethane nanoparticles (naked polyurethane, pegylated pol5mrethane, lysine-coated polyurea, biotinylated polyurethane-urea/pc DNA complex, and functionalized streptavidin-coated polyurethane-urea nanoparticles) obtained by interfacial polycondensation from O/W nano-emulsions (a) and transmission electron micrographs of polyurethane nanoparticles after being negatively stained with 1% v/v uranyl acetate (b).

CBO-Pll, a specific inhibitor of vascular endothelial growth factor and other angiogenic pathways, was efficiently incorporated in multifunctional anti-VC AM-1 and anti-ICAM-1 polyurethane-urea nanoparticles." These systems showed a significant and selective blockade of the proliferation only in inflamed endothelial cells and no cytotoxic effect was observed in healthy cells. Moreover, in vivo studies in CDl mice demonstrated that these nanoparticles reach the target site after intravenous administration. 

Figure 7.2 Design, uptake, and multitargeting of pegylated polyurethane-urea nanoparticles for theranostics. (a) Design of theranostic platform of pol5mrethane-urea and (b) theoretical mechanism of targeting and uptake of functionalized pegylated polyurethane-urea nanoparticles loading a therapeutic agent and fluorescent dye on tumor cells.

Melgar-Lesmes P, Morral-Rmz G, Solans C, Garcia-Cehna MJ. Quantifying the bioadhesive properties of surface-modified polyurethane-urea nanoparticles in the vascular network. Colloids SurfB Biointerfaces 2014 118 280-8. 

Functionalized pegylated polyurethane-urea nanoparticle for theranostics... 

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