Nicotine self-administration

DA receptor blockade is explained as due to the direct (rather than inverse) relationship between unitary dose of nicotine and response-rate in the dose-range selected for these experiments (ascending limb of the dose-effect function) (Corrigall and Coen, 1991). In fact, direct blockade of nicotine action at its receptor by mecamylamine or by chlorindosamine reduced the rate of responding for nicotine (Corrigall and Coen, 1991). [Pg.341]

Given the ability of neuroleptics and 6-OHDA lesions to impair responding for nicotine and for food, it is unclear to what extent their effect on nicotine self-administration is specifically related to an impairment of nicotine reinforcement. [Pg.341]

Rimonabant (382) has also shown promise in pre-clinical and clinical studies as an aid to smoking cessation. (382) decreases nicotine self-administration in rats and nicotine-induced dopamine release in nucleus acumbens [372], and also reversed nicotine-seeking behaviour in rats several weeks... [Pg.309]

Studies in knockout mice indicate that the p2 nAChRs are necessary for nicotine self-administration, DA-dependent locomotor activation, and nicotine-associated enhancement of NAc DA release.40-51 53 Combined with studies showing that antagonism of the high-affinity nAChRs block self-administration,44-54 it would appear that p2 nAChRs are particularly critical for nicotine reinforcement. Unlike wild-type mice that self-administer both cocaine and nicotine, p2 nAChR-null mutant mice learn to self-administer cocaine normally, but stop bar pressing as though receiving saline when cocaine is switched to nicotine.40 Self-administration of VTA nicotine and associated DA release is rescued, however, in p2 nAChR knockout mice with lentiviral-mediated expression of P2 subunit DNA in the VTA.55 Whereas several configurations of the p2 nAChRs exist at the... [Pg.26]

Epping-Jordan, M.P., Picciotto, M.R., Changeux, J.P., Pich, E.M. Assessment of nicotinic acetylcholine receptor subunit contributions to nicotine self-administration in mutant mice. Psychopharmacology (Berlin). 147 25, 1999. [Pg.33]

Markou, A., Paterson, N.E. The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat. Nicotine Tob. Res. 3 361, 2001. [Pg.34]

Corrigall, W.A., Coen, K.M., Zhang, J., Adamson, K.L. GABA mechanisms in the pedunculopontine tegmental nucleus influence particular aspects of nicotine self-administration selectively in the rat. Psychopharmacology (Berlin). 158 190, 2001. [Pg.34]

Caggiula, A.R., Donny, E.C., Chaudhri, N., Perkins, K.A., Evans-Martin, F.F., Sved, A.F. Importance of nonpharmacological factors in nicotine self-administration. Physiol. Behav. 77 683, 2002. [Pg.35]

Paterson, N.E., Semenova, S., Gasparini, F., Markou, A. The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology (Berlin). 167 257, 2003. [Pg.36]

Bespalov, A.Y., Dravolina, O.A., Sukhanov, I. et al. Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats. Neuropharmacology. 49(Suppl.) 167, 2005. [Pg.36]

Lesage, M.G., Keyler, D.E., Hieda, Y. et al. Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats. Psychopharmacology (Berlin). 1, 2005. [Pg.37]

Corrigall WA et al. Response of nicotine self-administration in the rat to manipulations of mu-opioid and gamma-aminobutyric acid receptors in the ventral tegmental area. Psychopharmacology 2000 149(2) 107-114. [Pg.459]

Lambe EK, Picciotto MR, Aghajanian GK (2003) Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex. Neuropsychopharmacology 28 216-225 Lanca AJ, Adamson KL, Coen KM, Chow BE, Corrigall WA (2000) The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat a correlative neuroanatomical and behavioral study. Neuroscience 96 735-742 Lawrence NS, Ross TJ, Stein EA (2002) Cognitive mechanisms of nicotine on visual attention. Neuron 36 539-548... [Pg.167]

Fu Y, Malta SG, Kane VB, Sharp BM (2003) Norepinephrine release in amygdala of rats during chronic nicotine self-administration an in vivo microdialysis study. Neuropharmacology 45 514-523... [Pg.199]

Donny EC, Chaudhri N, Caggiula AR, Evans-Martin FF, Booth S, Gharib MA, Clements LA, S ved AF (2003) Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine imphcations for nicotine self-administration and reinforcement. Psychopharmacology 169 68-76... [Pg.230]

Lecca D, CacciapagUa E, Valentini V, Gronli J, Spiga S, Di Chiara G (2006) Preferential increase of extracellular dopamine in the rat nucleus accumbens shell as compared to that in the core during acquisition and maintenance of intravenous nicotine self-administration. Psychopharmacology 184 435 46... [Pg.231]

Liechti ME, Markou A (2007) Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. Eur J Pharmacol 554 164-174 Lin D, Koob GP, Markou A (2000) Time-dependent alterations in ICSS thresholds associated with repeated amphetamine administrations. Pharmacol Biochem Behav 65 407-417... [Pg.231]

Overall, a limited number of experiments on rodents suggest that the upregulation of nicotinic receptors by nicotine treatment is observed in males but not females. On the other hand, nicotine self-administration has the same upregulation effect on both male and female rats. In human smokers, DA and 5-HT transporter availabihty appears to be higher in females than males although the difference is not substantial. [Pg.274]

Caggiula AR, Donny EC, et al (2001) Cue dependency of nicotine self-administration and smoking. Pharmacol Biochem Behav 70(4) 515-530... [Pg.285]

Caggiula AR, Donny EC, et al (2002) Environmental stimuli promote the acquisition of nicotine self-administration in rats. Psychopharmacology 163(2) 230-237 Caldarone BJ, Duman CH, et al (2000) Pear conditioning and latent inhibition in mice lacking the high afiBnity subclass of nicotinic acetylcholine receptors in the brain. Neuropharmacology 39(13) 2779-2784... [Pg.285]

Dluzen DE, Anderson LI (1997) Estrogen differentially modulates nicotine-evoked dopamine release from the striatum of male and female rats. Neurosci Lett 230(2) 140-142 Dluzen DE, Ramirez VD (1990) In vitro progesterone modulation of amphetamine-stimulated dopamine release from the corpus striatum of ovariectomized estrogen-treated female rats response characteristics. Brain Res 517(1-2) 117-122 Donny EC, Caggiula AR, et al (2000) Nicotine self-administration in rats estrous cycle effects, sex differences and nicotinic receptor binding. Psychopharmacology 151(4) 392-405... [Pg.285]

Many studies reviewed by Tanda and Goldberg (2000) have found evidence for interactions of nicotine with caffeine and drug discrimination studies have further expanded these investigations (Sect. 6.6). The bidirectional, dose-dependent nature of caffeine effects on nicotine discrimination invites comparisons with parallel studies of nicotine self-adminisfration. However, whereas very large chronic doses of caffeine that were much above those obtained by consumers of caffeinated beverages potentiated nicotine self-administration (Shoaib et al. 1999), there is a... [Pg.323]

Corrigall WA, Coen KM (1991) Selective dopamine antagonists reduce nicotine self- administration. Psychopharmacology 104 171-176... [Pg.326]

DeNoble VJ, Mele PC (2006) Intravenous nicotine self-administration in rats effects of mecamy-lamine, hexamethonium and naloxone. Psychopharmacology 184 266-272... [Pg.326]

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