GABA mechanism

Corrigall, W.A., Coen, K.M., Zhang, J., Adamson, K.L. GABA mechanisms in the pedunculopontine tegmental nucleus influence particular aspects of nicotine self-administration selectively in the rat. Psychopharmacology (Berlin). 158 190, 2001. 

GABA) mechanisms, and blockade of glutamatergic mechanisms. Because epilepsy is a disease with multiple etiologies, these combinations of mechanisms explain the clinical efficacy of this drug in this disease [78]. 

Gottesmann C GABA mechanisms and sleep. Neuroscience 2002 111 231. [PMID 11983310]... 

H. Fukuzako and K Izumi in G. Tunnicliffand B. U. Raess, Eds., GABA Mechanisms in Epilepsy, Wiley-Liss, New York, 1991, pp. 1-30. 

Understanding Alterations During Human Brain Development with Molecular Imaging Role in Determining Serotonin and GABA Mechanisms in Autism... 

Krogsgaard-Larsen, R, Larsson, O. M. and Schousboe, A. GABA Mechanism in Epilepsy,... 

Ferraz, HM.C., Pereira, F.L.C., Gonqalo, E.R.S., Santos, L.S., Eberlin, M.N. (2005) Unexpected Synthesis of Conformationally Restricted Analogues of y-Amino Butyric Acid (GABA) Mechanism Elucidation by Electrospray Ionization Mass Spectrometry. J. Org. Chem. 70 110-114. 

Unexpected synthesis of conformationally restricted analogues of gamma-amino butyric add (GABA) mechanism eluddation by electrospray ionization mass spectrometry. J. Org. Chem., 70, 110-114. 

Subunit changes are other mechanisms that alter the physiology of GABA synapses and account for plastic changes seen following chronic ethanol treatment. 

A second mechanism that impinges on the localization of transporters is through the association with proteins, the most prominent example being syntaxin. Syntaxin is a t-SNARE protein necessary for the fusion of vesicles with the plasma membrane (see the chapter on exocytosis). On the cell surface syntaxin consistently stabilizes the localization of GABA, noradrenaline, glycine, and 5HT transporters the PKCa isoform can sever the interaction with syntaxin suggesting a general mechanism for transporter internalization. 

Molecnlar Mechanisms Underlying Sleep Focns on GABA... 

The exocytotic release of neurotransmitters from synaptic vesicles underlies most information processing by the brain. Since classical neurotransmitters including monoamines, acetylcholine, GABA, and glutamate are synthesized in the cytoplasm, a mechanism is required for their accumulation in synaptic vesicles. Vesicular transporters are multitransmembrane domain proteins that mediate this process by coupling the movement of neurotransmitters to the proton electrochemical gradient across the vesicle membrane. 

The precise mechanism through which benzodiazepines and barbiturates produce mood elevation remains to be elucidated. The mood-elevating effect of the benzodiazepines and barbiturates is probably mediated not only by acute increases in the actions of GABA but also by neural connections from... 

Resistance to DDT has been developed in many insect species. Although there are some cases of metabolic resistance (e.g., strains high in DDT dehydrochlorinase activity), particular interest has been focused on kdr and super kdr mechanisms based upon aberrant forms of the sodium channel—the principal target for DDT. There are many examples of insects developing resistance to dieldrin. The best-known mechanism is the production of mutant forms of the target site (GABA receptor), which are insensitive to the insecticide. 

Brooks, G.T. (1992). Progress in structure-activity smdies on cage convnlsants and related GABA receptor chloride ionophore antagonists. In D. Otto and B. Weber (Eds.) Insecticides Mechanism of Action and Resistance. Newcastle npon Tyne, UK Intercept Press, 237-242. 

Of course, while the identification of these distinct systems may be useful there are many neural pathways that would not fit easily into one of them. Thus some inhibitory pathways, such as that from the caudate nucleus to substantia nigra, utilising GABA, are not intrinsic neurons. The dopamine pathway from the substantia nigra to striatum may start from a small nucleus but unlike other monoamine pathways it shows little ramification beyond its influence on the striatum. The object of the above classification is not to fit all neural pathways and mechanisms into a restricted number of functional categories but again to demonstrate that there are different forms of neurotransmission. 

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