Caffeine effect

Caffeine is a strong activator of CICR it sensitizes RyR to activating Ca2+ and increases the maximum attainable level. Because high concentrations (>mM) of caffeine effectively discharge Ca2+ from the Ca2+ store, it is frequently used for experimental evaluation of functional occurrence of RyRs. Caffeine is used for diagnosis of MH muscles biopsied from MH patients contract by a lower dose of caffeine than normal human, due to an enhanced CICR activity (see Disease)./Para>... 

Caffeine Effects on Psychological Functioning and Performance Barry D. Smith and Kenneth Tola... 

Given the general principles of the arousal model, we can derive several more specific hypotheses that are particularly relevant to caffeine effects. These hypotheses have been tested to varying degrees in the caffeine literature. 

France, C., Ditto, B., Caffeine effects on several indices of cardiovascular activity at rest and during stress. Journal of Behavioral Medicine 11(5), 473-482, 1988. 

Lane, J. D., Adcock, A., Williams, R. B., and Kuhn, C. M., Caffeine effects on cardiovascular and neuroendocrine responses to acute psychosocial stress and their relationship to level of habitual caffeine consumption. Psychosomatic Medicine 52, 320-336, 1990. 

Bernstein GA, Carroii ME, Crosby RD, Perwien AR, Go FS, Benowitz NL. (1994). Caffeine effects on iearning, performance, and anxiety in normai schooi-age chiidren. J Am Acad Child Adolesc Psychiatry. 33(3) 407-15. 

Many studies reviewed by Tanda and Goldberg (2000) have found evidence for interactions of nicotine with caffeine and drug discrimination studies have further expanded these investigations (Sect. 6.6). The bidirectional, dose-dependent nature of caffeine effects on nicotine discrimination invites comparisons with parallel studies of nicotine self-adminisfration. However, whereas very large chronic doses of caffeine that were much above those obtained by consumers of caffeinated beverages potentiated nicotine self-administration (Shoaib et al. 1999), there is a... 

Sparano, Nicole. Is the Combination of Ibuprofen Plus Caffeine Effective for the Treatment of Tension-type Headache Journal of Family Practice 50 (January 2001) 312-319. 

Lumley M, Roehrs T, Asker D. Ethanol and caffeine effects on daytime sleepi-ness/alertness. Sleep 1987 10 306-312. 

Johnson LC, Spinweber CL, Gomez SA. Benzodiazepines and caffeine effect on daytime sleepiness, performance, and mood. Psychopharmacology (Berl) 1990 101(2) 160-7. 

Any increased caffeine effects are normally unlikely to be of much importance in most people, but they might have a small part to play in exaggerating the undesirable effects of caffeine from food, drinks (e.g. tea, coffee, cola drinks, chocolate) and analgesics, which are sometimes formulated with caffeine. 

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