Neuronal nicotinic acetylcholine

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Bale AS, Smothers CT, Woodward JJ Inhibition of neuronal nicotinic acetylcholine receptors by the abused solvent, toluene. Br J Pharmacol 137 375-383, 2002... [Pg.303]

Picciotto, M.R., Caldarone, B J., Brunzell, D.H., Zachariou, V., Stevens, T.R., King, S.L. Neuronal nicotinic acetylcholine receptor subunit knockout mice physiological and behavioral phenotypes and possible clinical implications. Pharmacol. Ther. 92 89, 2001. [Pg.32]

Marubio, L.M., Gardier, A.M., Durier, S. et al. Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors. Eur. J. Neurosci. 17 1329, 2003. [Pg.34]

Turek, J.W., Kang, C.H., Campbell, J.E., Americ, S.P., Sullivan, J.P. A sensitive technique for the detection of the alpha 7 neuronal nicotinic acetylcholine receptor antagonist, methyllycaconitine, in rat plasma and brain. J. Neurosci. Methods. 61 113, 1995. [Pg.34]

Gopalakrishnan, M., Molinari, E., Sullivan, J. Regulation of human 0 ,P2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways. Mol. Pharmacol. 52 524, 1997. [Pg.48]

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Deneris ES, ConnoUy J, Boulter J, Wada E, Wada K, Swanson LW, Patrick J, Heinemann S (1988) Primary structure and expression of P2 A novel subunit of neuronal nicotinic acetylcholine receptors. Neuron 1 45-54... [Pg.106]

Leutje CW, Patrick J (1991) Both a- and 3-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors, J Neurosci 11 837-845 Lindstrom J (1998) Purification and cloning of nicotinic acetylcholine receptors. In Americ SP, Brioni JD (eds) Neuronal nicotinic receptors pharmacology and therapeutic opportunities. Wiley, New York, pp 3-23... [Pg.108]

Paton WDM, Zaimis EJ (1949) The pharmacological actions of polymethylene bistrimethylammo-nium salts. Br J Pharmacol Chemother 4 381 00 Patrick J, Stallcup WB (1977) a-Bungarotoxin binding and cholinergic receptor function on a rat sympathetic nerve line. J Biol Chem 252 8629-8633 Patrick J, Boulter J, Deneris E, Wada K, Wada E, Connolly J, Swanson L, Heinemann S (1989) Structure and function of neuronal nicotinic acetylcholine receptors deduced from cDNA clones. Prog Brain Res 79 27-33... [Pg.110]

Steinlein OK, MuUey JC, Propping P, Wallace RH, Phillips HA, Sutherland GR, Scheffer IE, Berkovic SF (1995) A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nat Genet 11 201-203... [Pg.111]

Inhaled nicotine is efficiently delivered to the brain (see chapter by Benowitz, this volume) where it selectively interacts with its central targets, the neuronal nicotinic acetylcholine receptors (nAChRs). The multiple subtypes of uAChR (see chapter by Collins et al, this volume) all bind nicotine but with different affinities, depending on the subunit composition of the uAChR. Binding may result in activation or desensitisation of uAChRs, reflecting the temporal characteristics of nicotine dehvery and local concentration of nicotine. Another level of complexity of the actions of nicotine reflects the widespread and non-uniform distribution of uAChR subtypes within the brain, such that nicotine can influence many centrally regulated functions in addition to the reward systems. In this chapter, we address the consequences of nicotine interactions with nAChRs at the molecular, cellular and anatomical levels. We critically evaluate experimental approaches, with respect to their relevance to human smoking, and contrast the acute and chronic effects of nicotine. [Pg.174]

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Cronan T, Conrad J, et al (1985) Effects of chronically administered nicotine and sahne on motor activity in rats. Pharmacol Biochem Behav 22(5) 897-899 Curtis L, Buisson B, et al (2002) Potentiation of human alpha4beta2 neuronal nicotinic acetylcholine receptor by estradiol. Mol Pharmacol 61(1) 127-135 Dalton JC, Vickers GJ, et al (1986) Increased self-administration of cocaine following haloperidol sex-dependent effects of the antiestrogen tamoxifen. Pharmacol Biochem Behav 25(3) 497-501 Damsma G, Day J, et al (1989) Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens. Eur J Pharmacol 168(3) 363-368 Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85(14) 5274-5278... [Pg.285]

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Decker MW, Anderson DJ, Brioni ID, DonneUy-Roberts DL, Kang CH, O Neill AB, Piattoni-Kaplan M, Swanson S, SuUivan IP (1995) Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, Eur J Pharmacol 280 79-89 Dekeyne A, Girardon S, MUlan Ml (1999) Discriminative stimulus properties of the novel serotonin (5-HT)2c receptor agonist, Ro 60-0175 a pharmacological analysis. Neuropharmacology 38 415-423... [Pg.326]

Colquhoun LM, Patrick JW. Pharmacology of neuronal nicotinic acetylcholine receptor subtypes. Adv Pharmacol 1997 39 191-220. [Pg.309]

Sargent PB. The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 1993 16 403-43. [Pg.310]

Steinlein OK, Deckert J, Nothen MM, Franke P, Maier W, Beckmann H, Propping P (1997) Neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) and panic disorder an association study. Am J Med Genet 74 199-201 Sylvester CE, Hyde TS, Reichler RJ (1988) Clinical psychopathology among children of adults with panic disorder. In Barrett JE (ed) Relatives at Risk for Mental Disorder, vol 48. Raven Press, New York, pp 928-934... [Pg.178]

E. R. Spindel (2003). Neuronal nicotinic acetylcholine receptors not just in brain. Am. J. Physiol. [Pg.300]

Smulders CJ et al Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase. Toxicol Appl Pharmacol 2003 193 139. [PMID 14644616]... [Pg.151]

Bannon, A. W., Decker, M. W., Holladay, M. W., Curzon, P., Donnelly-Roberts, D. L., Puttfarcken, P. S., Bitner, R. S., Diaz, A., Dickenson, A. H., Porsolt, R. D., Williams, M., Arneric, S. P. Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors, Science 1998, 279, 77-81. [Pg.442]

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