Neuron nicotinic

Jensen AA, Frolund B, Liljefors T et al (2005) Neuronal nicotinic acetylcholine receptors structural revelations, target identifications, and therapeutic inspirations. J Med Chem 48 4705—4745... 

Bale AS, Smothers CT, Woodward JJ Inhibition of neuronal nicotinic acetylcholine receptors by the abused solvent, toluene. Br J Pharmacol 137 375-383, 2002... 

Few drugs, apart from nicotine itself, act specifically on nicotine receptors. One is methylcarbachol, which lacks the muscarinic effects of carbachol and another is dimethylphenylpiperazinium (DMPP), which appears to have some selectivity for the neuronal nicotinic receptor. Neither of them can cross the blood-brain barrier. 

Picciotto, M.R., Caldarone, B J., Brunzell, D.H., Zachariou, V., Stevens, T.R., King, S.L. Neuronal nicotinic acetylcholine receptor subunit knockout mice physiological and behavioral phenotypes and possible clinical implications. Pharmacol. Ther. 92 89, 2001. 

Marubio, L.M., Gardier, A.M., Durier, S. et al. Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors. Eur. J. Neurosci. 17 1329, 2003. 

Turek, J.W., Kang, C.H., Campbell, J.E., Americ, S.P., Sullivan, J.P. A sensitive technique for the detection of the alpha 7 neuronal nicotinic acetylcholine receptor antagonist, methyllycaconitine, in rat plasma and brain. J. Neurosci. Methods. 61 113, 1995. 

Peng, X., Gerzanich, V., Anand, R., Whiting, P, Lindstrom, J. Nicotine-induced increase in neuronal nicotinic receptor results from a decrease in the rate of receptor turnover. Mol. Pharmacol. 46 523, 1994. 

Gopalakrishnan, M., Molinari, E., Sullivan, J. Regulation of human 0 ,P2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways. Mol. Pharmacol. 52 524, 1997. 

Narahashi T, Aistrup GL, Marszalec W and Nagata K (1999). Neuronal nicotinic acetylcholine receptors A new target site for ethanol. Neurochemistry International, 35, 131-141. 

Le Novere N, Zoli M, Changeux JP. Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain. Eur J Neurosci 1996 8(ll) 2428-2439. Picciotto MR et al. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 1995 374(6517) 65-67. 

Rao TS, Correa LD, Lloyd GK. (1997). Effects of lobeline and dimethyl-phenylpiperazinium iodide (DMPP) on N-methyl-D-aspartate (NMDA)-evoked acetylcholine release in vitro evidence for a lack of involvement of classical neuronal nicotinic acetylcholine receptors. Neuropharmacology. 36(1) 39-50. 

Badio B, Padgett WL, Daly JW. (1997). Ibogaine a potent noncompetitive blocker of ganglionic/neuronal nicotinic receptors. Mol Pharmacol. 51(1) 1-5. 

Hill JA Jr, Zoli M, Bourgeois JP, Changeux JR 1993. Immu-nocytochemical localization of a neuronal nicotinic receptor the P2 subunit. J Neurosci 13 1551-1568. 

Wada E, Wada K, Boulter J, Deneris E, Heinemann S, et al. 1989. Distribution of al, a3, a4, and 32 neuronal nicotinic receptor subunit mRNAs in the central nervous system a hybridization histochemical study in the rat. J Comp Neurol 284 314-335. 

The Road to Discovery of Neuronal Nicotinic Cholinergic Receptor Subtypes... 

Azam L, Winzer-Serhan UH, Chen Y, Leslie FM (2002) Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons. 1 Comp Neurol 444 260-274... 

Ballivet M, Nef P, Couturier S, Rungger D, Bader CR, Bertrand D, Cooper E (1988) Electrophysiology of a chick neuronal nicotinic acetylcholine receptor expressed in Xenopus oocytes after cDNA injection. Neuron 1 847-852... 

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