Neuronal Nicotinic Receptors

Few drugs, apart from nicotine itself, act specifically on nicotine receptors. One is methylcarbachol, which lacks the muscarinic effects of carbachol and another is dimethylphenylpiperazinium (DMPP), which appears to have some selectivity for the neuronal nicotinic receptor. Neither of them can cross the blood-brain barrier. [Pg.128]

Peng, X., Gerzanich, V., Anand, R., Whiting, P, Lindstrom, J. Nicotine-induced increase in neuronal nicotinic receptor results from a decrease in the rate of receptor turnover. Mol. Pharmacol. 46 523, 1994. [Pg.47]

Le Novere N, Zoli M, Changeux JP. Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain. Eur J Neurosci 1996 8(ll) 2428-2439. Picciotto MR et al. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 1995 374(6517) 65-67. [Pg.459]

Badio B, Padgett WL, Daly JW. (1997). Ibogaine a potent noncompetitive blocker of ganglionic/neuronal nicotinic receptors. Mol Pharmacol. 51(1) 1-5. [Pg.535]

Hill JA Jr, Zoli M, Bourgeois JP, Changeux JR 1993. Immu-nocytochemical localization of a neuronal nicotinic receptor the P2 subunit. J Neurosci 13 1551-1568. [Pg.290]

Wada E, Wada K, Boulter J, Deneris E, Heinemann S, et al. 1989. Distribution of al, a3, a4, and 32 neuronal nicotinic receptor subunit mRNAs in the central nervous system a hybridization histochemical study in the rat. J Comp Neurol 284 314-335. [Pg.291]

Hogg RC, Bertrand D (2004) Neuronal nicotinic receptors and epilepsy, from genes to possible therapeutic compounds. Bioorganic Med Chem Lett 14 1859-1861... [Pg.107]

Leutje CW, Patrick J (1991) Both a- and 3-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors, J Neurosci 11 837-845 Lindstrom J (1998) Purification and cloning of nicotinic acetylcholine receptors. In Americ SP, Brioni JD (eds) Neuronal nicotinic receptors pharmacology and therapeutic opportunities. Wiley, New York, pp 3-23... [Pg.108]

Parrott AC (2003) Cigarette-derived nicotine is not a medicine. World J Biol Psychiatry 4 49-55 Parrott AC, Kaye FJ (1999) Daily uplifts, hassles, stresses and cognitive failures in cigarette smokers, abstaining smokers, and non-smokers. Behav Pharmacol 10 639-646 Paterson D, Nordberg A (2000) Neuronal nicotinic receptors in the human brain. Prog Neurobiol 61 75-111... [Pg.168]

Ellers H, Schaeffer E, Bidder PE, Forsayeth JR (1997) Functional deactivation of the major neuronal nicotinic receptor caused by nicotine and a protein kinase C-dependent mechanism. Mol Pharmacol 52 1105-1112... [Pg.199]

Nuutinen S, Barik J, Jones IW, Wonnacott S (2007) Differential effects of acute and chronic nicotine on Elk-1 in rat hippocampus. Neuroreport 18 121-126 Olale E, Gerzanich V, Kuryatov A, Wang E, Lindstrom J (1997) Chronic nicotine exposure differentially affects the function of human alpha3, alpha4, and alpha7 neuronal nicotinic receptor subtypes. J Pharmacol Exp Ther 283 675-683... [Pg.203]

Xiao Y, KeUar KJ (2004) The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammahan cells. 1 Pharmacol Exp Ther 10 98-107... [Pg.208]

Quick MW, Lester RA (2002) Desensitization of neuronal nicotinic receptors. J Neurobiol 53 457 78... [Pg.509]

Memantine is the first in a novel class of Alzheimer s disease medications acting a.o. on the NMDA receptor of the glutamatergic system. It also acts as an uncompetitive antagonist at different neuronal nicotinic receptors at potencies possibly similar to the NMDA receptor. Memantine is approved for treatment of moderate to severe Alzheimer s disease and its use is associated with a moderate decrease in clinical deterioration of the disease. Common adverse drug reactions (>1% of patients) include confusion, dizziness, drowsiness, headache, insomnia, agitation, and/or hallucinations. [Pg.359]

Clementi F, Fornasari D, and Gotti C. (eds). Neuronal Nicotinic Receptors. Berlin Springer Verlag, 2000. [Pg.147]

Luetje CW, Patrick J Both a and P-subunits contribute to the agonist sensitivity of neuronal nicotinic receptors. J Neurosci 11 837-845, 1991... [Pg.687]

V. Itier, D. Bertrand (2001). Neuronal nicotinic receptors from protein structure to function. FEES Lett. 504 118-125. [Pg.300]

Neuronal nicotinic receptors are present on sensory nerve endings—especially afferent nerves in coronary arteries and the carotid and aortic bodies as well as on the glomus cells of the latter. Activation of these receptors by nicotinic stimulants and of muscarinic receptors on glomus cells by muscarinic stimulants elicits complex medullary responses, including respiratory alterations and vagal discharge. [Pg.139]

Lobeline A Natural Product with High Affinity for Neuronal Nicotinic Receptors and a Vast Potential for Use in Neurological Disorders Christopher R. McCurdy, Reagan L. Miller, and ]. Warren Beach... [Pg.13]

Clementi, F., Fornasari, D., Gotti, C. Neuronal nicotinic receptor, important new players in brain function, Eur. J. Pharmcol. 2000, 393, 3-10. [Pg.442]

Flores, C. M., Hargreaves, K. M. Neuronal nicotinic receptors New targets in the treatment of pain, in Neuronal nicotinic receptors Pharmacology and therapeutic opportunities, edited by S. P. [Pg.443]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...