Discriminative stimulus properties

To summarize the data in table 1, neither MDMA nor MBDB has hallu-cinogen-like discriminative stimulus properties. Symmetrical transfer of the MDMA and MBDB stimulus indicates that their primary discriminative stimulus effects are very similar. For both MDMA and MBDB, there is enantioselectivity for the S isomer, with about a twofold eudismic ratio. Finally, the substitution of (- )-amphetamine and cocaine in MDMA-trained rats may indicate that MDMA has some psychostimulant-like properties, while hffiDB seems to lack this activity. 

Undoubtedly, nonneurotoxic entactogens can and will be discovered. Sufficient evidence already exists to support this hypothesis. We know, for example, from the work of Schechter (1986) that the discriminative stimulus properties of MDMA are largely dissipated within 4 hours of drug administration. On the other hand, Schmidt (1987) has shown that MDMA... 

Evans, S.M., and Johanson, C.E. Discriminative stimulus properties of ( )-3,4-methylenedioxymethamphetamine, and ( )-3,4-methylenedioxy-amphetamine in pigeons. Drug Alcohol Depend 18 159-164, 1986. 

Glennon, R.A., and Young, R. Further investigation of the discriminative stimulus properties of MDA. Pharmacol Biochem Behav 20 501-505, 1984a. 

White, F.J., and Appel, J.B. A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine. Psychopharmacology (Berlin) 73 110-115, 1981. 

Glennon, R.A. Rosecrans, J.A. and Anderson, G.M. Discriminative stimulus properties of MDA analogs. Biol Psychiatry 17 807-814, 1982. 

Huang, J.T., and Ho, B.T. Discriminative stimulus properties of d-amphetamine and related compounds in rats. Pharmacol Biochem Behav 2 569-673, 1974b. 

Young, R., and Glennon, R.A. Discriminative stimulus properties of amphetamine and structurally related phenalkylamines. Med Res Rev 6 99-130, 1986. 

Silverman, P.B., and Ho, B.T. The discriminative stimulus properties of 2,5-dimethoxy-4-methylamphetamine (DOM) Differentiation from amphetamine. Psychopharmacology (Berlin) 68 209-215, 1980. 

Brady, K.T. Balster, R.L. and May, E.L. Discriminative stimulus properties of stereoisomers of N-allylnormetazocine in phencyclidine-trained squirrel monkeys and rats. Science 215 178-180, 1982. 

Shannon, H.E. Evaluation of phencyclidine analogs on the basis of their discriminative stimulus properties in the rat. 

Shannon, H.E. Pharmacological analysis of the phencyclidine-1ike discriminative stimulus properties of narcotic derivatives in rats. J. Pharmacol Fxp Ther 222 146-151, 1982b. 

Another characteristic of PCP which has been studied with great interest over the last 5 years, is the ability of PCP to produce a discriminative stimulus in monkeys, rats, and pigeons. As discussed elsewhere in this volume, by Browne, the discriminative stimulus properties of PCP are shared not only by other members of the arylcycloalkylamine class, but by psychotomimetic benzo-morphans and substituted dioxolanes. The structure-activity relationships (SAR) within and between these classes are virtually identical to those found when studying the displacement of 3H-PCP from its binding site in rat brain membranes. This correlation... 

The most interesting aspects of the studies reviewed here are that the drugs having discriminative stimulus properties similar to PCP also produce ipsilateral turning and that this behavior is well correlated with both affinity for the PCP/sigma receptor and the ability to inhibit the effects of NMDA on transmitter release in the striatum. Although inhibition of NMDA-induced DA release was... 

Shearman, G.T., and Herz, A. Non-opioid psychmotomimetic-11ke discriminative stimulus properties of N-al lylnormetazocine (SKF-10,047) in the rat. lur J Pharmacol 82 167-172, 1982. 

Browne, R.G., and Kozlowski, M.R. High affinity 3H-PCP binding sites predict discriminative stimulus properties in rats. In preparation. 

Shannon, H.E. Pharmacological evaluation of N-al 1 ylnormetazocine (SKF10,047) on the basis of its discriminative stimulus properties in the rat. J. Pharmacol Fxp Ther 225 144-152, 1983. Shearman, G.T., and Herz, A. Non-opioid psychotomimetic-like discriminative stimulus properties of N-allylnormetazocine (SKF 10,047) in the rat. fur J Pharmacol 82 167-172, 1982. 

Ukai M., Mori E., Kameyama T. Effects of centrally administered neuropeptides on discriminative stimulus properties of cocaine in the rat. Pharmacol. Biochem. Behav. 51 705, 1995. 

Young, R., Glennon, R. A., and Rosecrans, J. A. (1983) Discriminative stimulus properties of 5-methoxy-N,N-dimethyltryptamine and its dose dependent antagonism by BC-105. Psycho-... 

Dopaminergic system, LSD-induced alterations of, 159-160 Dorsal raphe nucleus (DRN) injection of LSD, morphine, and methadone into, comparison of discriminate stimulus properties of, 84, 85... 

FIG. 2. Comparison of the discriminative stimulus properties of LSD, morphine, and methadone when injected into the DRN of the rat. Rats were trained to discriminate LSD (120 ng/kg s.c.), cannulae implanted, and generalization from peripheral to central administration determined over a variety of doses of each drug. (Redrawn from the research of Rosecrans and Glennon, ref. 59.) A, I.C. saline, , I.C. morphine in morphine trained rats, O, I.C. saline, , I.C. LSD in LSD trained rats, , I.C. saline, , I.C. methadone in methadone trained rats. 

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