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Neurogenesis and Brain Repair

Keywords Doublecortin Epidermal grow th factor Fibroblast growth factor Nestin Progenitor cells Stem cells, Radial glia Rostral migratory stream Subventricular zone Subgranular zone [Pg.445]

Hallbergson AF, Gnatenco C, Peterson DA (2003) Neurogenesis and brain injury Managing a renewable resource for repair. J Clin Invest 112 1128-1133. [Pg.459]

Sun, Y. E., Martinovich, K. and Gee, W. Making and repairing the mammalian brain-signaling toward neurogenesis and gliogenesis. Semin. Cell Dev. Biol. 14 161-168, 2003. [Pg.457]

Volume I, Adult Neurogenesis and Neural Stem Cells, provides an overview and in-depth analysis of the new field of stem cell research that is the generation of new neuronal cells and the existence of stem cells, in the adult brain of mammals. These discoveries have forced us to re-think and re-evaluate how the brain is functioning, and reveal that the adult brain has the potential for self-repair. This volume covers the basic science of adult neurogenesis and neural stem cell research, from the origin, mechanisms, function, and the therapeutic potential of adult NSCs. [Pg.2]

Sohur US, Emsley JG, Mitchell BD, Macklis JD (2006) Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells. Philos Trans R Soc Lond B Biol Sci 361 1477-1497. [Pg.462]

The confirmation that neurogenesis occurs in the adult brain and that NSCs reside in the adult CNS opens new opportunities for cellular therapy. Cell therapy would involve the stimulation of endogenous neural progenitor or stem cells, or the transplantation of adult-derived neural progenitor and stem cells to repair the degenerated pathways. [Pg.96]

Lorente de No R (1934) Studies on the structure of the cerebral cortex. II. Continuation of the study of the Ammonic system. J Psychol Neurol 46 113-177 Love S, Barber R, Wilcock GK (1998) Apoptosis and expression of DNA repair proteins in ischaemic brain injury in man. Neuroreport 9 955-959 Love S, Barber R, Wilcock GK (1999) Neuronal accumulation of poly(ADP-ribose) after brain ischaemia. Neuropathol Appl Neurobiol 25 98-103 Luskin MB (1993) Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 11 173-189 Magavi SS, Leavitt BR, Macklis JD (2000) Induction of neurogenesis in the neocortex of adult mice. Nature 405 951-955... [Pg.102]

Oka A, Takashima S, Abe M, Araki R, Takeshita K. 2000. Expression of DNA-dependent protein kinase catalytic subunit and Ku80 in developing human brains Implications of DNA-repair in neurogenesis. Neurosci Lett 292 167-170. Okabe S. 2007. Molecular anatomy of the postsynaptic density. Mol Cell Neurosci 34 503-518. [Pg.233]

Stem cell-based therapy for cerebral ischemia will be more complicated, because the extensive cell death and massive inflammatory response make these brains a more hostile environment for cell grafts. Various sources of cells have been tested for their ability to reconstruct the forebrain and improve function after transplantation in animal models of stroke (Lindvall and Kokaia, 2004). In most cases, only a few grafted cells could survive. Some recent exciting findings in rodents suggest that stroke can induce an increase in neurogenesis thus, a new therapeutic approach based on self-repair has been brought forth, as discussed in Sect. 13.11.1. [Pg.163]

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